Monthly Archives: June 2012

Cannabis and tobacco smoke are not equally carcinogenic

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“Cannabis and tobacco smoke are not equally carcinogenic… Cannabis smoke contains cannabinoids whereas tobacco smoke contains nicotine (plus added carcinogens). Available scientific data, that examines the carcinogenic properties of inhaling smoke and its biological consequences, suggests reasons why tobacco smoke, but not cannabis smoke, may result in lung cancer… Furthermore, compounds found in cannabis have been shown to kill numerous cancer types including: lung cancer, breast and prostate, leukemia and lymphoma, glioma, skin cancer, and pheochromocytoma…”-

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1277837/?tool=pubmed

Concomitant consumption of marijuana, alcohol and tobacco in oral squamous cell carcinoma development and progression: Recent advances and challenges

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“Carcinogens found in tobacco are also concentrated in marijuana, but the latter also contains high levels of cannabinoids, bioactive compounds responsible for several effects such as euphoria and analgesia. However, Δ(9)-tetrahydrocannabinol (Δ(9)-THC), the major psychotropic cannabinoid found in plants, causes a reduction of cellular metabolism and induction of apoptosis (progarmmed cell death), both of which are anti-neoplastic properties…”

http://www.ncbi.nlm.nih.gov/pubmed/22727410 

Cannabis derivatives therapy for a seronegative stiff-person syndrome: a case report

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“Stiff-person syndrome (SPS) is an uncommon and disabling disorder… Cannabis derivatives [tetrahydrocannabinol (THC) and cannabidiol (CBD)] are available as an oromucosal spray (Sativex(®)… Our objective is to report a case of seronegative SPS successfully treated with THC-CBD oromucosal spray… THC-CBC can be an option for SPS patient. Our case report suggests that THC-CBD oromucosal spray is an alternative treatment for patients with refractory SPS…”

http://www.ncbi.nlm.nih.gov/pubmed/22726074 

Cannabinoid-mediated antinociception is enhanced in rat osteoarthritic knees

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“Cannabinoid-mediated antinociception is enhanced in rat osteoarthritic (OA) knees… application of the CB(1) agonist significantly reduced the firing rate of afferent nerve fibers… These findings indicate that activation of peripheral CB(1) receptors reduces the mechanosensitivity of afferent nerve fibers in control and OA knee joints. As such, peripheral CB(1) receptors may be important targets in controlling OA pain.”

http://www.ncbi.nlm.nih.gov/pubmed/18163511

Characterisation of the cannabinoid receptor system in synovial tissue and fluid in patients with osteoarthritis and rheumatoid arthritis

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“Cannabis-based medicines have a number of therapeutic indications, including anti-inflammatory and analgesic effects… cannabis-based drugs have therapeutic potential in inflammatory diseases, including rheumatoid arthritis (RA) and multiple sclerosis (MS)…aim of this study was to determine whether the key elements of the endocannabinoid signalling system.. are expressed in the synovia of patients with osteoarthritis (OA) or RA… Our data predict that the cannabinoid receptor system present in the synovium may be an important therapeutic target for the treatment of pain and inflammation associated with OA and RA.”

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2453762/?tool=pubmed

Cannabis Use in Patients with Fibromyalgia: Effect on Symptoms Relief and Health-Related Quality of Life

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“We observe significant improvement of symptoms of FM in patients using cannabis… knowledge of the endocannabinoid system and the role of the stress system in the pathopysiology of FM suggest a new approach to the suffering of these patients… results together with previous evidence seem to confirm the beneficial effects of cannabinoids on FM symptoms.”

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080871/?tool=pubmed

Cannabinoids Induce Apoptosis of Pancreatic Tumor Cells via Endoplasmic Reticulum Stress–Related Genes

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“The hemp plant Cannabis sativa produces unique compounds known as cannabinoids, of which Δ9-tetrahydrocannabinol (THC) is the most important… The present study was undertaken to investigate the antitumoral action of cannabinoids in pancreatic cancer and the molecular mechanisms involved in that effect… Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genes…These findings may contribute to set the basis for a new therapeutic approach for the treatment of pancreatic cancer.”

http://cancerres.aacrjournals.org/content/66/13/6748.long

Delta9-tetrahydrocannabinol inhibits cell cycle progression in human breast cancer cells through Cdc2 regulation.

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” Here, we show that Delta(9)-tetrahydrocannabinol (THC), through activation of CB(2) cannabinoid receptors, reduces human breast cancer cell proliferation by blocking the progression of the cell cycle and by inducing apoptosis… these data might set the bases for a cannabinoid therapy for the management of breast cancer.”

http://www.ncbi.nlm.nih.gov/pubmed/16818634

 

Cannabis-induced cytotoxicity in leukemic cell lines: the role of the cannabinoid receptors and the MAPK pathway

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“We therefore investigated the role of the CB-Rs (CannaBinoid-Receptors) in mediating apoptosis in 3 leukemic cell lines… We have shown that THC is a potent inducer of apoptosis… THC-induced cell death…”

http://bloodjournal.hematologylibrary.org/content/105/3/1214.long

Harvard Study: Marijuana Cuts Lung Cancer Tumor Growth In Half

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“The active ingredient in marijuana cuts tumor growth in common lung cancer in half and significantly reduces the ability of the cancer to spread, say researchers at Harvard University who tested the chemical in both lab and mouse studies.”

http://www.sciencedaily.com/releases/2007/04/070417193338.htm