| “An Israeli researcher has found that tiny doses of the psychoactive chemical in marijuana helps the brain of mice combat injury.”
“The words “marijuana” and “brain damage” usually go in that order in medical literature. An Israeli researcher has flipped them around, finding that THC, the active ingredient in marijuana, may arrest some forms of brain damage in mice. The loco weed already is favored by those who suffer from chronic diseases, not to mention fans of Cypress Hill, Bob Marley and the Grateful Dead. But pharmacologist Josef Sarne of Tel Aviv University found that a minuscule amount of tetrahydrocannabinol may protect the brain after injuries from seizures, toxic drug exposure or a lack of oxygen.” |
“Extremely low doses of THC, the psychoactive component of marijuana, protects the brain from long-term cognitive damage in case of injury from hypoxia (lack of oxygen), seizures, or toxic drugs, a new study has claimed.
Medical cannabis is often used by sufferers of chronic ailments, including cancer and post-traumatic stress disorder, to combat pain, insomnia, lack of appetite, and other symptoms.
Now, Professor Yosef Sarne of Tel Aviv University’s Adelson Center for the Biology of Addictive Diseases at the Sackler Faculty of Medicine in US found the drug has neuroprotective qualities as well.
Previous studies focused on injecting high doses of THC within a very short time frame approximately 30 minutes before or after injury.
Sarne’s current research, published in the journals Behavioural Brain Research and Experimental Brain Research, demonstrates that even extremely low doses of THC around 1,000 to 10,000 times less than that in a conventional marijuana cigarette administered over a wide window of 1 to 7 days before or 1 to 3 days after injury can jump start biochemical processes which protect brain cells and preserve cognitive function over time.
This treatment, especially in light of the long time frame for administration and the low dosage, could be applicable to many cases of brain injury and be safer over time, Sarne said.
While performing experiments on the biology of cannabis, researchers found that low doses of the drug had a big impact on cell signalling, preventing cell death and promoting growth factors.
This finding led to a series of experiments designed to test the neuroprotective ability of THC in response to various brain injuries.
In the lab, the researchers injected mice with a single low dose of THC either before or after exposing them to brain trauma. A control group of mice sustained brain injury but did not receive the THC treatment.”
http://www.indianexpress.com/news/marijuana-component-can-halt-brain-damage/1123274/
“Though marijuana is a well-known recreational drug, extensive scientific research has been conducted on the therapeutic properties of marijuana in the last decade. Medical cannabis is often used by sufferers of chronic ailments, including cancer and post-traumatic stress disorder, to combat pain, insomnia, lack of appetite, and other symptoms.
Now Prof. Yosef Sarne of Tel Aviv University’s Adelson Center for the Biology of Addictive Diseases at the Sackler Faculty of Medicine says that the drug has neuroprotective qualities as well. He has found that extremely low doses of THC—the psychoactive component of marijuana—protects the brain from long-term cognitive damage in the wake of injury from hypoxia (lack of oxygen), seizures, or toxic drugs. Brain damage can have consequences ranging from mild cognitive deficits to severe neurological damage.
Previous studies focused on injecting high doses of THC within a very short time frame—approximately 30 minutes—before or after injury. Prof. Sarne’s current research, published in the journals Behavioural Brain Research and Experimental Brain Research, demonstrates that even extremely low doses of THC—around 1,000 to 10,000 times less than that in a conventional marijuana cigarette—administered over a wide window of 1 to 7 days before or 1 to 3 days after injury can jumpstart biochemical processes which protect brain cells and preserve cognitive function over time.
This treatment, especially in light of the long time frame for administration and the low dosage, could be applicable to many cases of brain injury and be safer over time…”
More: http://medicalxpress.com/news/2013-05-doses-marijuana-component-brain-injury.html
“Though marijuana is a well-known recreational drug, extensive scientific research has been conducted on the therapeutic properties of marijuana in the last decade. Medical cannabis is often used by sufferers of chronic ailments, including cancer and post-traumatic stress disorder, to combat pain, insomnia, lack of appetite and other symptoms.
Now Prof. Yosef Sarne of Tel Aviv Univ.’s Adelson Center for the Biology of Addictive Diseases at the Sackler Faculty of Medicine says that the drug has neuroprotective qualities as well. He has found that extremely low doses of THC — the psychoactive component of marijuana — protects the brain from long-term cognitive damage in the wake of injury from hypoxia (lack of oxygen), seizures or toxic drugs. Brain damage can have consequences ranging from mild cognitive deficits to severe neurological damage.
Previous studies focused on injecting high doses of THC within a very short time frame — approximately 30 minutes — before or after injury. Sarne’s current research, published in the journals Behavioural Brain Research and Experimental Brain Research, demonstrates that even extremely low doses of THC — around 1,000 to 10,000 times less than that in a conventional marijuana cigarette — administered over a wide window of one to seven days before or one to three days after injury can jumpstart biochemical processes which protect brain cells and preserve cognitive function over time.
This treatment, especially in light of the long time frame for administration and the low dosage, could be applicable to many cases of brain injury and be safer over time, Sarne says.”
More: http://www.laboratoryequipment.com/news/2013/05/marijuanas-thc-can-halt-brain-damage
“Hasn’t pot always been considered harmful?
Not at all. Marijuana, the dried form of the plant Cannabis sativa, was used as an herbal remedy for centuries in China, the Middle East, and Asia. William O’Shaughnessy, a physician for the East India Tea Company, brought it west in the 1830s as a treatment for rheumatism, tetanus, and rabies. It was commonly prescribed as a pain reliever in the U.S. until the 1930s, when its growing popularity caused such concern that the newly founded Federal Bureau of Narcotics reclassified it as a narcotic. The bureau soon launched a decidedly unscientific campaign claiming that marijuana use provoked insanity, homicidal tendencies, and uncontrollable lust. The marijuana user, the bureau asserted, “becomes a fiend with savage or ‘caveman’ tendencies. His sex desires are aroused, and some of the most horrible crimes result.””
“Was there any evidence for such claims?
None; in fact, the American Medical Association argued against marijuana prohibition in the 1930s, citing its therapeutic potential. But the bureau made its case that marijuana was “dangerous for the mind and the body,” and the federal government outlawed its use in 1937. It wasn’t until the 1970s that a campaign began to restore marijuana’s therapeutic reputation, and in 1996 California became the first state to legalize cannabis for medicinal purposes. Psychiatrist Tod Mikuriya, a founding father in the medical marijuana movement, claimed that cannabis has none of the adverse side effects of opiates. “In fact,” he said, “it really enhances both quality of life and rehabilitation.””
More: http://theweek.com/article/index/236671/is-marijuana-bad-for-you
“A working paper published Monday (PDF) claims that, despite the insistence of numerous U.S. officials, legalizing medical marijuana had no distinguishable effect on teen drug abuse rates in the surrounding communities.”
“Marijuana and hydrocodone are two of the most widely used and abused drugs in the U.S. But according to a new study by one of the nation’s largest drug screening companies, chronic pain patients who are prescribed hydrocodone are less likely to take the painkiller if they are using marijuana.”
“A smokeless cannabis-vaporizing device delivers the same level of active therapeutic chemical and produces the same biological effect as smoking cannabis…
…smoked cannabis can alleviate the chronic pain caused by HIV-related neuropathy, but a concern was expressed that smoking cannabis was not safe. This study demonstrates an alternative method that gives patients the same effects and allows controlled dosing but without inhalation of the toxic products in smoke,” said study lead author Donald I. Abrams, MD, UCSF professor of clinical medicine.
…pills tend to provide patients with more THC than they need for optimal therapeutic effect and increase side effects.
Patients rated the “high” they experienced from both smoking and vaporization and there was no difference between the two methods by patient self-report of the effect, according to study findings. In addition, patients were asked which method they preferred.
“By a significant majority, patients preferred vaporization to smoking, choosing the route of delivery with the fewest side effects and greatest efficiency,” said Benowitz.”
Read more: http://www.sciencedaily.com/releases/2007/05/070515151145.htm
“The development of oral cancer is not a result of smoking cannabis per se; rather, it is hypothesized to be a result of contracting hpv through various forms of sharing and passing joints and other smoking apparatuses. Therefore, it is hypothesized that bogarting (and not passing) joints might decrease oral hpv among cannabis smokers.
It certainly may not be the cannabis smoke that causes oral cancers in heavy cannabis users. Most people who have ever smoked cannabis have most likely done so by sharing a rolled cigarette or pipe in a group setting. The sharing and passing of these smoking devices from an oral hpv-infected individual to an uninfected individual could easily provide a route of transmission for the virus between users. Frequency and setting should therefore be considered two major factors that might contribute to the likelihood of acquiring oral hpv.
Thus, the relationship between cannabis and various cancer types might not be from cannabis use itself, but rather from contracting high-risk types of oral hpv that lead to cancer in later life.”