“Several lines of evidence strongly implicate a dysfunctional endocannabinoid system (ECS) in eating disorders…
These data point to a widespread transient disturbance of the endocannabinoid transmission, specifically for CB1 receptors in the ABA model. Our data also suggest (1) gender effects on regional CB1 receptor binding in the hippocampus and (2) add further proof to the validity of the ABA model to mimic aspects of human disease.”
“This study aimed to determine the cellular distribution of islet cannabinoid receptors (CBs) and their involvement in the development of metabolic and hormonal changes in rats fed a fructose-rich diet (F)…
Cannabinoid receptors appeared exclusively in islet α cells…
Islet CBs would exert an important modulatory role in metabolic homeostasis…
Selective islet CB1 blockers could be useful to prevent/treat the alterations induced by the intake of unbalanced/unhealthy diets.”
“Cannabis-based drug for type 2s on the way?”
The company, GW Pharma, is in the process of creating a collection of cannabinoid-based drugs, including one that takes aim at diabetes. The first of this type of drug the company has produced is Sativex, a nasal spray used to treat spasms associated with multiple sclerosis. Sativex has been okayed in eight countries, and is currently awaiting FDA approval in the United States.
The diabetes drug, GWP4204, is currently in its second phase of testing after a small but successful double-blind study. That study featured 62 type 2 patients who received various levels of the oral-administered drug or a placebo.”
More: http://diabeteshealth.com/read/2013/07/20/7933/cannabis-derived-drug-for-type-2-enters-phase-2–
“The protective effect of cannabidiol, the non-psychoactive component of Cannabis sativa, against liver toxicity induced by a single dose of cadmium chloride was investigated in rats…
It was concluded that cannabidiol may represent a potential option to protect the liver tissue from the detrimental effects of cadmium toxicity.”
“Marijuana also found to prevent pain associated with chemotherapy”
“Studies in Spain have shown findings that Tetrahydrocannabinol (THC), the active ingredient found in marijuana, can induce the death of brain cancer cells, according to scientist Guillermo Velasco and his research team from the School of Biology at Complutense University in Madrid.
In a laboratory study where mice were “engineered” to carry three varying kinds of human cancer tumor grafts, THC was introduced into the brain, triggering a self-digestion development on a cellular level, known as “autophagy.” Within this process, the research team managed to isolate the particular activation route from which this process evolved.
The research team was also conducting clinical trials in concert, on two consenting brain cancer patients, said to be suffering from a rapidly aggressive form of cancer, known as “recurrent glioblastoma multiforme.”
The team, using electron microscopes to analyze brain tissue extracted before and after the 26 to 30-day regime, found that the THC had eradicated cancer cells, leaving the healthy cells undamaged.
The findings can now lend themselves to future design in newer cancer therapies, using the concept of autophagy activation.”
More: http://guardianlv.com/2013/08/cannabis-kills-cancer-cells/
“A new study published by the journal J-Stage, and funded by the Ministry of Education, Culture, Sports, Science and Technology of Japan, has found that cannabinoids – whether THC, CBD or CBDV – were effective at blocking a certain enzyme which is known to cause cancer, and is produced in large amount when cigarettes are consumed.”
“These results suggest that the pentylresorcinol structure in CBD may have structurally important roles in direct CYP1A1 inhibition, although the whole structure of CBD is required for overall inhibition”, according to researchers.
CYP1A1 is an enzyme which isn’t dangerous at low-levels, but is produced in large quantities when someone smokes cigarettes; at large doses, the enzyme has been linked to cancer.
Researchers state that; “Accordingly, CBD and its related compounds, which are potent inhibitors of CYP1A1 activity, would be useful as a lead compound in anticancer chemotherapy.””
“Marijuana Disrupts Cancer Pathway of Cigarettes: Study” http://www.truthonpot.com/2013/08/19/marijuana-disrupts-cancer-pathway-of-cigarettes-study/
“Thanks to the available findings of a 2006 study showing that cannabis actually reduces the number of cancer cells, medical marijuana users can now feel even better about the widely abolished pain relief ingredient found in the plant. The relationship between marijuana and cancer has always been up for debate, but with the use of a specially crafted oil made from the buds of the Cannabis Sativa plant, scientists confirmed that the plant’s primary psychoactive chemical tetrahydrocannabinol (THC) destroys any and all malignant cancer cell growths in several patients. Details on the marijuana and cancer prevention connection aren’t exactly known, but further, more extensive testing will reveal exactly what may be causing this seemingly miracle cure.”
“Ovarian cancer represents one of the leading cause of cancer-relateddeaths for women and is the most common gynecologic malignancy.In spite of relative low morbidity, ovarian cancer has a highfatality ratio, with overall 5-year survival of less than 30%.At present, there are inadequate treatment options for the managementof advanced ovarian cancer, and therefore development of novelapproaches for treatment of this disease are needed.
Cannabinoids,the active components of Cannabis sativa linnaeous and their derivatives have received considerable attention in recent yearsdue to their diverse pharmacological activities such as cell growth inhibition and tumor regression. To date, two differentcannabinoid receptors have been characterized and cloned frommammalian tissues: the “central” CB1 receptor and the “peripheral”CB2 receptor…
These results support a new therapeutic approach for the treatmentof ovarian cancer. It is also conceivable that with available cannabinoids as lead compounds, non-habit forming agents that have higher biological effects could be developed.”
http://www.aacrmeetingabstracts.org/cgi/content/abstract/2006/1/1084
http://cancerres.aacrjournals.org/content/66/8_Supplement/1084.1
“New research out of Spain suggests that THC — the active ingredient in marijuana — appears to prompt the death of brain cancer cells.”
“Toxicology and Carcinogenesis Studies of 1-Trans-[Delta.sup.9]-Tetrahydrocannabinol
Summation of above:
“Thus, in our studies, rats and mice that received THC for 2 years exhibited body weight reductions, enhanced survival rates, and decreased tumor incidences in several sites, mainly organs under hormonal control. These earlier experimental carcinogenesis results on THC clearly lend further validity to the notion that cannabinoids may indeed be anticarcinogenic.””
link
http://www.thefreelibrary.com/Antitumor+Effects+of+THC-a06814…