“The cancer preventive effects of edible mushrooms…dietary components may exert cancer preventive effects.”  http://www.ncbi.nlm.nih.gov/pubmed/22583406

“Reishi (Ganoderma lucidum)”

“Anti-cancer properties of triterpenoids isolated from Ganoderma lucidum…”  http://www.ncbi.nlm.nih.gov/pubmed/23790022

“Button mushrooms (Agaricus bisporus)” 

“Macrophage immunomodulating and antitumor activities of polysaccharides isolated from Agaricus bisporus… Mushroom polysaccharides are known for their immunomodulating and antitumor properties… antitumor effects of Agaricus polysaccharides.” http://www.ncbi.nlm.nih.gov/pubmed/22217303

“A. blazei, oyster mushrooms (Pleurotus ostreatus),” 

“Anti-tumor and immunomodulating effects of Pleurotus ostreatus…could be used as immunomodulators and anti cancer agents.”  http://www.ncbi.nlm.nih.gov/pubmed/16782541

“Shiitake mushrooms (Lentinus edodes),” 

“A novel polysaccharide from Lentinus edodes Mycelia exhibits potential antitumor activity…could be explored as a potential antitumor material…”  http://www.ncbi.nlm.nih.gov/pubmed/23955351

“and maitake (Grifola frondosa)”

“Antitumor effects of a water-soluble extract from Maitake (Grifola frondosa) on human gastric cancer cell lines…potential antitumor effects on gastric cancer.”  http://www.ncbi.nlm.nih.gov/pubmed/19639212

“From time immemorial, mushrooms have been valued by humankind as a culinary wonder and folk medicine…The chief medicinal uses of mushrooms discovered so far are as anti-oxidant, anti-diabetic, hypocholesterolemic, anti-tumor, anti-cancer, immunomodulatory, anti-allergic, nephroprotective, and anti-microbial agents. The mounting evidences from various research groups across the globe, regarding anti-tumor application of mushroom extracts unarguably make it a fast-track research area worth mass attention.” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339609/

“Compounds from wild mushrooms with antitumor potential.”  http://www.ncbi.nlm.nih.gov/pubmed/20545620

“Anti-Cancer Effects of Protein Extracts from Calvatia lilacina (CL), Pleurotus ostreatus (PO) and Volvariella volvacea (VV)… widely distributed worldwide and commonly eaten as mushrooms…the protein extracts of these mushrooms could be considered an important source of new anti-cancer drugs…”  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139501/

“Calvatia lilacina (CL),” 

“Calvatia lilacina protein-extract induces apoptosis through glutathione depletion in human colorectal carcinoma cells. This paper reports that a novel protein extract isolated from Calvatia lilacina (CL) can induce cell death against four types of human colorectal cancer cells…we report here for the first time the anticancer effect of CL on human colorectal cancer cells…CL can thus provide the basis for the strategic design of a treatment of colorectal cancer.”  http://www.ncbi.nlm.nih.gov/pubmed/19182949

“Pleurotus ostreatus (PO),” 

“Pleurotus ostreatus inhibits proliferation of human breast and colon cancer cells…our results indicated that the edible oyster mushroom has potential therapeutic/preventive effects on breast and colon cancer.”  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2796484/

“and Volvariella volvacea (VV)”

“Isolation and characterization of a lectin from edible mushroom, Volvariella volvacea… The lectin has a moderate inhibitory effect on the growth of tumor cells.” http://www.ncbi.nlm.nih.gov/pubmed/6541650

“Structures and antitumor activities of polysaccharides isolated from mycelium of Volvariella volvacea.” http://www.ncbi.nlm.nih.gov/pubmed/1368842

“Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides. The number of mushrooms on Earth is estimated at 140,000, yet maybe only 10% (approximately 14,000 named species) are known. Mushrooms comprise a vast and yet largely untapped source of powerful new pharmaceutical products. In particular, and most importantly for modern medicine, they represent an unlimited source of polysaccharides with antitumor and immunostimulating properties.” http://www.ncbi.nlm.nih.gov/pubmed/12436306

“Antitumor activity of mushroom polysaccharides: a review.”  http://www.ncbi.nlm.nih.gov/pubmed/22865023

“The protein extracts of CL, PO and VV can be considered as a source of potential cancer therapeutic agents.” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139501/

“Pleurotus ostreatus inhibits proliferation of human breast and colon cancer cells… our results indicated that the edible oyster mushroom has potential therapeutic/preventive effects on breast and colon cancer.”  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2796484/

“An aqueous polysaccharide extract from the edible mushroom Pleurotus ostreatus induces anti-proliferative and pro-apoptotic effects…Here, we describe a newly identified low-molecular-weight alpha-glucan with promising anti-tumorigenic properties, and demonstrate its direct effect on colon cancer cell proliferation via induction of programmed cell death.”  http://www.ncbi.nlm.nih.gov/pubmed/16413114

“Anti-tumor and immunomodulating effects of Pleurotus ostreatus mycelia-derived proteoglycans…proteoglycans derived from the mushroom (P. ostreatus) mycelia could be used as immunomodulators and anti cancer agents.” http://www.ncbi.nlm.nih.gov/pubmed/16782541

“Anti-inflammatory activity of edible oyster mushroom (Pleurotus ostreatus)… Mushrooms have been used, as a source of food and for their medicinal (generally anticancer) properties, since ancient times. A number of biologically active compounds, including polysaccharides, vitamins, terpenes, steroids, amino acids, and trace elements, have been identified in different mushroom species…In conclusion, the results of our study show that the edible oyster mushroom possesses anti-inflammatory activity. As such, the mushroom and its extract or concentrate, can be considered a functional food that has the potential to control inflammation.” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3120742/

“Anti-inflammatory plant natural products for cancer therapy.”http://www.ncbi.nlm.nih.gov/pubmed/20432202

“Cytotoxic effect of oyster mushroom Pleurotus ostreatus on human androgen-independent prostate cancer PC-3 cells. A water-soluble extract (POE) prepared from the fresh oyster mushroom Pleurotus ostreatus produced the most significant cytotoxicity on PC-3 cells among the mushroom species tested.”  http://www.ncbi.nlm.nih.gov/pubmed/16822205

“Effect of oyster mushroom (Pleurotus ostreatus) on pathological changes in dimethylhydrazine-induced rat coloncancer…a reduction in total number of tumours was observed in both groups of animals fed mushroom diet.”  http://www.ncbi.nlm.nih.gov/pubmed/9538185

“The role of apoptosis, proliferative cell nuclear antigen (PCNA) and p53 protein in the preventive effects of dietary fiber treated with the fungus Pleurotus ostreatus on rat-colon tumorigenesis was studied… corncob (treated with the fungus Pleurotus ostreatus) inhibits colon cancer development, and, therefore, may considered of potential use to the public.”  http://www.ncbi.nlm.nih.gov/pubmed/9216672

“Anti-Cancer Effects of Protein Extracts from… Pleurotus ostreatus…protein extracts of these mushrooms could be considered an important source of new anti-cancer drugs.” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139501/

“White button mushroom (Agaricus bisporus) exhibits antiproliferative and proapoptotic properties and inhibits prostate tumor growth… White button mushrooms are a widely consumed food containing phytochemicals beneficial to cancer prevention. The purpose of this research was to evaluate the effects of white button mushroom extract and its major component, conjugated linoleic acid (CLA) on prostate cancer cell lines in vitro and mushroom extract in vivo… The data provided by this study illustrate the anticancer potential of phytochemicals in mushroom extract both in vitro and in vivo and supports the recommendation of white button mushroom as a dietary component that may aid in the prevention of prostate cancer in men.” http://www.ncbi.nlm.nih.gov/pubmed/19005974

“Anti-Aromatase Activity of Phytochemicals in White Button Mushrooms (Agaricus bisporus). White button mushrooms (Agaricus bisporous) are a potential breast cancer chemopreventive agent, as they suppress aromatase activity and estrogen biosynthesis. Therefore, we evaluated the activity of mushroom extracts in the estrogen receptor–positive/aromatase-positive MCF-7aro cell line in vitro and in vivo… our studies illustrate the anticancer activity in vitro and in vivo of mushroom extract and its major fatty acid constituents.” http://cancerres.aacrjournals.org/content/66/24/12026.long

“Hericium erinaceus (Lion’s Mane) mushroom extracts inhibit metastasis of cancer… edible mushrooms have the potential to serve as a health-promoting functional food.” http://www.ncbi.nlm.nih.gov/pubmed/23668749

“Antimetastatic and immunomodulating effect of water extracts from various mushrooms.” http://www.ncbi.nlm.nih.gov/pubmed/20633495

“[Immunological study on the antitumor effects of fungus polysaccharides compounds]” http://www.ncbi.nlm.nih.gov/pubmed/12725070

“Antitumor and immunoenhancing activities of polysaccharide from culture broth of Hericium spp. The fruiting body and culture broth of many edible mushrooms contain water-soluble polysaccharides. Numerous researchers have reported that these polysaccharides have immunoenhancing effects. In this study,” http://www.ncbi.nlm.nih.gov/pubmed/11842649

“It has been demonstrated that the Hericium erinaceus (HE) mushroom, which primarily consists of polysaccharides, possesses anti-tumor activities…These findings suggest that HE… serves as an effective tool for treating drug-resistant human hepatocellular carcinoma.” http://www.ncbi.nlm.nih.gov/pubmed/20554107

“Mechanism of Hericium erinaceus (Yamabushitake) mushroom-induced apoptosis of U937 human monocytic leukemia cells. Phytochemicals in some foods are a potential source of bioactive safe compounds for cancer chemoprevention and suppression of tumor initiation, promotion, and metastasis… we evaluated… Hericium erinaceus (Yamabushitake, Lion’s Mane) mushrooms for their ability to induce apoptosis (programmed cell death) in human leukemia cells…The results indicate that H. erinaceus mushrooms may have therapeutic potential against human leukemia.”  http://www.ncbi.nlm.nih.gov/pubmed/21779573

“Composition and mechanism of antitumor effects of Hericium erinaceus mushroom extracts in tumor-bearing mice.”  http://www.ncbi.nlm.nih.gov/pubmed/21846141

“Potential activity of aqueous extract of culinary-medicinal Lion’s Mane mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (Aphyllophoromycetideae) in accelerating wound healing…” http://www.ncbi.nlm.nih.gov/pubmed/22135902

“Neuroregenerative potential of lion’s mane mushroom, Hericium erinaceus…”  http://www.ncbi.nlm.nih.gov/pubmed/23510212

“Hericium erinaceus: an edible mushroom with medicinal values…anti-cancer, immuno-modulating, hypolipidemic, antioxidant and neuro-protective activities of this mushroom. H. erinaceus has also been reported to have anti-microbial, anti-hypertensive, anti-diabetic, wound healing properties among other therapeutic potentials.” http://www.ncbi.nlm.nih.gov/pubmed/23735479

“Most chemotherapeutic agents for the treatment of cancer can destroy tumors and arrest cancer progress but cancer treatment may damage healthy cells and tissues. Thus, new anticancer drugs from natural products are expected to play an important role in the development of more effective and safer agents to inhibit the onset of cancer… Anticancer activity of subfractions containing pure compounds of Chaga mushroom (Inonotus obliquus) extract in human cancer cells..In conclusion, the three subfractions (3β-hydroxy-lanosta-8,24-dien-21-al, inotodiol, and lanosterol) inhibited in vitro proliferation of various human cancer cell lines… 3β-hydroxy-lanosta-8,24-dien-21-al, inotodiol, and lanosterol may therefore be interesting compounds for the development of novel anticancer drugs and functional anticancer food.” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895696/

“Anti-cancer effect and structural characterization of endo-polysaccharide from cultivated mycelia of Inonotus obliquus.”  http://www.ncbi.nlm.nih.gov/pubmed/16458328

“Anticancer effects of fraction isolated from fruiting bodies of Chaga medicinal mushroom, Inonotus obliquus (Pers.:Fr.) Pilát (Aphyllophoromycetideae): in vitro studies.” http://www.ncbi.nlm.nih.gov/pubmed/22135889

“Antitumor and immunomodulatory activity of water-soluble polysaccharide from Inonotus obliquus.” http://www.ncbi.nlm.nih.gov/pubmed/22840014

“Identification of Inonotus obliquus and analysis of antioxidation and antitumor activities of polysaccharides.” http://www.ncbi.nlm.nih.gov/pubmed/18795365

“Antitumor activity of water extract of a mushroom, Inonotus obliquus…”  http://www.ncbi.nlm.nih.gov/pubmed/19367670

“Progress on understanding the anticancer mechanisms of medicinal mushroom: inonotus obliquus. Cancer is a leading cause of death worldwide. Recently, the demand for more effective and safer therapeutic agents for the chemoprevention of human cancer has increased. As a white rot fungus, Inonotus obliquus is valued as an edible and medicinal resource. Chemical investigations have shown that I. obliquus produces a diverse range of secondary metabolites, including phenolic compounds, melanins, and lanostane-type triterpenoids. Among these are active components for antioxidant, antitumoral, and antiviral activities and for improving human immunity against infection of pathogenic microbes…polysaccharides from I. obliquus can indirectly be involved in anticancer processes mainly via stimulating the immune system. Furthermore, the antioxidative ability of I. obliquus extracts can prevent generation of cancer cells… mechanisms underlying the anticancer influence of I. obliquus…”  http://www.ncbi.nlm.nih.gov/pubmed/23679238

“In vitro antitumor activity and structure characterization of ethanol extracts from wild and cultivated Chaga medicinal mushroom, Inonotus obliquus (Pers.:Fr.) Pilát (Aphyllophoromycetideae).” http://www.ncbi.nlm.nih.gov/pubmed/22135888

“Potential anticancer properties of the water extract of Inonotus obliquus by induction of apoptosis in melanoma cells…This study showed that the water extract of Inonotus obliquus mushroom exhibited a potential anticancer activity against melanoma cells in vitro and in vivo through the inhibition of proliferation and induction of differentiation and apoptosis of cancer cells…”  http://www.ncbi.nlm.nih.gov/pubmed/19041933

“Comparative study of antioxidant activity and antiproliferative effect of hot water and ethanol extracts from the mushroom Inonotus obliquus.” http://www.ncbi.nlm.nih.gov/pubmed/19147108

“Anti-inflammatory and anticancer activities of extracts and compounds from the mushroom Inonotus obliquus.” http://www.ncbi.nlm.nih.gov/pubmed/23561137

“Chaga mushroom (Inonotus obliquus)…Chaga mushroom may provide a new therapeutic option, as a potential anticancer agent…”  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2681140/

“Medicinal mushrooms and cancer therapy: translating a traditional practice into Western medicine… novel anticancer agents are being sought from traditional medicine… Purified bioactive compounds derived from medicinal mushrooms are a potentially important new source of anticancer agents.”  http://www.ncbi.nlm.nih.gov/pubmed/16702701

“New scientific approaches to cancer treatment: can medicinal mushrooms defeat the curse of the century? Unfortunately, our age, heredity, lifestyle, race, and ethnicity are directly connected to the development of carcinogenesis… It is already well established that medicinal mushrooms represent a potential source for biologically active compounds with immunomodulating, free radical scavenging, anti-inflammatory, antibacterial, antifungal, antiviral, hepatoprotective, antidiabetic, and anticancer activities… low-molecular weight mushroom substances… representing a new scientific approach to cancer treatment and prevention.”  http://www.ncbi.nlm.nih.gov/pubmed/22339703

“Medicinal mushroom modulators of molecular targets as cancer therapeutics..high-molecular-weight polysaccharides or polysaccharide-protein complexes from mushrooms appear to enhance innate and cell-mediated immune responses, exhibit antitumor activities in animals and humans, and demonstrate anticancer properties”  http://www.ncbi.nlm.nih.gov/pubmed/15726350

“Antitumor activity of mushroom polysaccharides: a review” http://www.ncbi.nlm.nih.gov/pubmed/22865023

“Bioactive polysaccharides from traditional Chinese medicine herbs as anticancer adjuvants.” http://www.ncbi.nlm.nih.gov/pubmed/12470436

“Immunomodulatory and anti-tumour polysaccharides from medicinal plants.”  http://www.ncbi.nlm.nih.gov/pubmed/7895893

“Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides. The number of mushrooms on Earth is estimated at 140,000, yet maybe only 10% (approximately 14,000 named species) are known. Mushrooms comprise a vast and yet largely untapped source of powerful new pharmaceutical products. In particular, and most importantly for modern medicine, they represent an unlimited source of polysaccharides with antitumor and immunostimulating properties.” http://www.ncbi.nlm.nih.gov/pubmed/12436306

“Recent developments in mushrooms as anti-cancer therapeutics: a review. From time immemorial, mushrooms have been valued by humankind as a culinary wonder and folk medicine in Oriental practice…The chief medicinal uses of mushrooms discovered so far are as anti-oxidant, anti-diabetic, hypocholesterolemic, anti-tumor, anti-cancer, immunomodulatory, anti-allergic, nephroprotective, and anti-microbial agents.The mounting evidences from various research groups across the globe, regarding anti-tumor application of mushroom extracts unarguably make it a fast-track research area worth mass attention.” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339609/

“Biotechnological cultivation of edible macrofungi: an alternative for obtaining nutraceutics” http://www.ncbi.nlm.nih.gov/pubmed/22449697

“Therapeutic potential of various beta-glucan sources in conjunction with anti-tumor monoclonal antibody in cancer therapy.”  http://www.ncbi.nlm.nih.gov/pubmed/19106638

“Commonly consumed and specialty dietary mushrooms reduce cellular proliferation in human breastcancer cells…both common and specialty mushrooms may be chemoprotective against breast cancer.”  http://www.ncbi.nlm.nih.gov/pubmed/20921274

“Enhanced antiproliferative effects of aqueous extracts of some medicinal mushrooms on colon cancer cells. Auricularia polytricha, Macrolepiota procera, and Pleurotus ostreatus…the aqueous extracts of all 3 species of mushrooms have a remarkable irreversible antiproliferative effect on cancer cell lines… treatment with the extracts validated the anticancerous property of these mushroom species.”  http://www.ncbi.nlm.nih.gov/pubmed/23662617

“Effect of various natural products on growth of bladder cancer cells: two promising mushroom extracts… GD- and PL-fractions…It is thus plausible that these substances could be used, solely or combined with conventional modalities, for the treatment of superficial bladder cancer.”  http://www.ncbi.nlm.nih.gov/pubmed/17397268

“Anticancer Activity of Amauroderma rude… medicinal mushrooms have been widely used as a miraculous herb for health promotion, especially by cancer patients… we found that the extract of Amauroderma rude exerted the highest activity in killing most of these cancer cell lines…Taken together, Amauroderma rude represented a powerful medicinal mushroom with anti-cancer activities.” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3688780/

“Medicinal mushroom Phellinus linteus as an alternative cancer therapy.”  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3445909/

“Phellinus linteus activates different pathways to induce apoptosis in prostate cancer cells…polysaccharides extracted from the Phellinus linteus (PL) mushroom possess antitumour activity.” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360058/

“Dramatic remission of hormone refractory prostate cancer achieved with extract of the mushroom, Phellinus linteus.” http://www.ncbi.nlm.nih.gov/pubmed/15331908

“Protein-bound polysaccharide from Phellinus linteus inhibits tumor growth, invasion, and angiogenesis in human colon cancer cells. Polysaccharides extracted from the Phellinus linteus (PL) mushroom are known to possess anti-tumor effects…These data suggest that PL suppresses tumor growth, invasion, and angiogenesis through the inhibition of Wnt/β-catenin signaling in certain colon cancer cells.” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154178/

“Phellinus linteus suppresses growth, angiogenesis and invasive behaviour of breast cancer cells…our study suggests potential therapeutic effect of PL against invasive breast cancer.” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361714/

“Mycelial Extract of Phellinus linteus Induces Cell Death in Lung Cancer Cells…  may be a potential therapeutic agent for the control of human lung carcinoma cells.”  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769563/

“Constituents isolated from Cordyceps militaris suppress enhanced inflammatory mediator’s production and human cancer cell proliferation. The present study provides scientific supporting information for the ethnopharmacological use of Cordyceps militaris as an anti-inflammatory and anticancer agent.”  http://www.ncbi.nlm.nih.gov/pubmed/20633630

“Antifungal and Anticancer Activities of a Protein from the Mushroom Cordyceps militaris… These results indicate that C. militaris represents a source of a novel protein that might be applied in diverse biological and medicinal applications…mushroom C. militaris could be used as a nutraceutical for cancer patients, and also as a fungicide or for meat tenderizer.” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2766723/

“Cordycepin-enriched Cordyceps militaris induces immunomodulation and tumor growth delay in mouse-derived breast cancer. Cordyceps militaris (C. militaris) and its main functional component, cordycepin, has been shown to possess a number of pharmacological activities including immunological stimulation and antitumor effects. ” http://www.ncbi.nlm.nih.gov/pubmed/23921598

“Induction of apoptosis by aqueous extract of Cordyceps militaris…Cordyceps militaris is well known as a traditional medicinal mushroom and has been shown to exhibit immunostimulatory and anticancer activities.”  http://www.ncbi.nlm.nih.gov/pubmed/19131705

“Anticancer, antioxidant and antibiotic activities of mushroom Ramaria flava… These results suggest that R. flava could hold a good potential source for human health.” http://www.ncbi.nlm.nih.gov/pubmed/23684998