The antinociceptive effect of Delta9-tetrahydrocannabinol in the arthritic rat.

Posted on December 3, 2014 by David

“Our study addressed the hypothesis that spinal release of endogenous opioids underlies Delta9-tetrahydrocannabinol (Delta9-THC)-induced antinociception in Freund’s adjuvant-induced arthritic and nonarthritic rats…

Our results indicate that morphine or Delta9-THC is equally potent and efficacious in both nonarthritic and arthritic rats.

Delta9-THC-induced antinociception…

We hypothesize that the elevated idyn A level in arthritic rats contributes to hyperalgesia by interaction with N-methyl-D-aspartate receptors, and that Delta9-THC induces antinociception by decreasing idyn A release.”

http://www.ncbi.nlm.nih.gov/pubmed/15189765

http://www.thctotalhealthcare.com/category/arthritis/

The antinociceptive effect of Delta9-tetrahydrocannabinol in the arthritic rat involves the CB(2) cannabinoid receptor.

Posted on December 3, 2014 by David

“Cannabinoid CB(2) receptors have been implicated in antinociception in animal models of both acute and chronic pain.

We evaluated the role both cannabinoid CB(1) and CB(2) receptors in mechanonociception in non-arthritic and arthritic rats.

The antinociceptive effect of Delta(9)-tetrahydrocannabinol (Delta(9)THC) was determined…

Our results indicate that the cannabinoid CB(2) receptor plays a critical role in cannabinoid-mediated antinociception, particularly in models of chronic inflammatory pain.”

http://www.ncbi.nlm.nih.gov/pubmed/17588560

http://www.thctotalhealthcare.com/category/arthritis/

http://www.thctotalhealthcare.com/category/pain-2/

Cannabinoids and muscular pain. Effectiveness of the local administration in rat.

Posted on December 3, 2014 by David

“Pain associated with musculoskeletal disorders can be difficult to control and the incorporation of new approaches for its treatment is an interesting challenge.

Activation of cannabinoid (CB) receptors decreases nociceptive transmission in acute, inflammatory and neuropathic pain states…

Our results provide evidence that both, CB 1 and CB 2 receptors can contribute to muscular antinociception and, interestingly, suggest that the local administration of CB agonists could be a new and useful pharmacological strategy in the treatment of muscular pain, avoiding adverse effects induced by systemic administration.”

http://www.ncbi.nlm.nih.gov/pubmed/22354705

http://www.thctotalhealthcare.com/category/pain-2/

Involvement of central and peripheral cannabinoid receptors on antinociceptive effect of tetrahydrocannabinol in muscle pain.

Posted on December 3, 2014 by David

“Cannabinoid (CB) receptors have emerged as an attractive therapeutic target for pain management in recent years and the interest in the use of cannabinoids is gradually increasing, particularly in patients where conventional treatments fail…

This study suggests that THC could be a future pharmacological option in the treatment of muscle pain.

The local administration of THC could be an interesting option to treat this type of pain avoiding the central adverse effects.”

http://www.ncbi.nlm.nih.gov/pubmed/25446925

http://www.thctotalhealthcare.com/category/pain-2/