Reduction by Δ9-tetrahydrocannabinol in the blood pressure of hypertensive rats bearing regenerated adrenal glands

Posted on April 1, 2015 by David

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“A suspension of (−)-Δ9-trans-tetrahydrocannabinol (Δ9-THC) was administered daily for one week by i.p. injection to female rats showing the syndrome of adrenal regeneration hypertension (ARH)…

The findings indicate that Δ9-THC, at a moderate dose for the rat, is capable of lowering the blood pressure in rats suffering from adrenal regeneration hypertension and that chronic administration of Δ9-THC does not appear to stimulate the pituitary-adrenal axis, in contrast to reported effects of acute administration.”

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1776093/

http://www.thctotalhealthcare.com/category/hypertension-high-blood-pressure/

Propagation through alginate encapsulation of axillary buds of Cannabis sativa L. — an important medicinal plant

Posted on April 1, 2015 by David

“Cannabis sativa L. (Cannabaceae) is an important medicinal plant well known for its pharmacologic and therapeutic potency…

These plants are selected to be used in mass cultivation for the production of biomass as a starting material for the isolation of THC as a bulk active pharmaceutical.”

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3550375/

http://www.thctotalhealthcare.com/category/thc-delta-9-tetrahydrocannabinol/

Differential effect of cannabinol and cannabidiol on THC-induced responses during abstinence in morphine-dependent rats.

Posted on April 1, 2015 by David

“The same dose of cannabinol (CBN) or cannabidiol (CBD) further increased the attenuation of precipitated abstinence signs observed in morphine-dependent rats that also received an acute dose of delta 9-THC. By contrast, rotational behavior (turning), which is observed concomitantly in THC-treated rats during morphine abstinence, was not increased by CBN, but was potentiated by CBD.

These data illustrate differences between psychoinactive cannabinoids in their interaction with delta 9-THC that might be relevant to possible clinical use of Cannabis in narcotic detoxification.”

http://www.ncbi.nlm.nih.gov/pubmed/1237925

Differential expression of cannabinoid receptors in the human colon: cannabinoids promote epithelial wound healing.

Posted on April 1, 2015 by David

“An immunomodulatory role for the endocannabinoid system in gastrointestinal inflammatory disorders has been proposed and this study sought to determine the location of both cannabinoid receptors in human colon and to investigate epithelial receptor function.

The location of CB1 and CB2 receptors in human colonic tissue was determined by immunohistochemistry…

Cannabinoids enhanced epithelial wound closure…

CONCLUSIONS:

CB1 receptors are expressed in normal human colon and colonic epithelium is responsive biochemically and functionally to cannabinoids. Increased epithelial CB2-receptor expression in human inflammatory bowel disease tissue implies an immunomodulatory role that may impact on mucosal immunity.”

http://www.ncbi.nlm.nih.gov/pubmed/16083701

Cannabinoid receptor type 2 is time-dependently expressed during skin wound healing in mice.

Posted on April 1, 2015 by David

“Dynamic localization of CB2R and quantitative analysis of CB2R mRNA during skin wound healing in mice were performed…

In conclusion, dynamic distribution and expression of CB2R suggest that CB2R is involved in modulating macrophages and myofibroblasts in response to inflammatory event and repair process in mouse skin wound healing, and CB2R is available as a marker for wound age determination.”

http://www.ncbi.nlm.nih.gov/pubmed/22814434

The cannabinoid receptor type 2 is time-dependently expressed during skeletal muscle wound healing in rats.

Posted on April 1, 2015 by David

“The expression of the cannabinoid receptor type 2 (CB2R) was investigated by immunohistochemistry, Western blotting, and RT-PCR during wound healing of contused skeletal muscle in rats with attempt of its applicability to skeletal muscle wound age estimation…

In conclusion, dynamic distribution and expression of CB2R suggest that CB2R be involved in modulating macrophages in response to inflammatory event in rat skeletal muscle wound healing and CB2R be available as a marker for wound age determination.”

http://www.ncbi.nlm.nih.gov/pubmed/20535492

[Expression of cannabinoid receptor I during mice skin incised wound healing course].

Posted on April 1, 2015 by David

“To investigate the expression of cannabinoid receptor I (CB1R) during mice skin incised wound healing course and time-dependent changes of CB1R in wound age determination…

The control group showed a low expression of CB1R detected mainly in epidermis, hair follicles, sebaceous gland and dermomuscular layer. CB1R expression was undetectable in neutrophils in the wound specimens from 6h to 12h post-injury.

The positive bands of CB1R were observed in all time points of the wound healing course…

CONCLUSION:

CB1R is activated during the wound healing course. The expression of CB1R is found in mononuclear cells, which could be involved in inflammation reaction. CBIR is observed in fibroblastic cells, which could participate in the wound healing. CB1R may be a potentially useful marker for determination of wound healing age.”

http://www.ncbi.nlm.nih.gov/pubmed/20967946