“The aim of this study was to characterize inhibitory mechanisms on T cell receptor signaling mediated by the cannabinoid receptors CB1 and CB2. Both receptors are coupled to G(i/o) proteins, which are associated with inhibition of cyclic AMP formation…

These findings help to better understand the immunosuppressive effects of cannabinoids and explain the beneficial effects of these drugs in the treatment of T cell-mediated autoimmune disorders like multiple sclerosis.

To sum up, our results help to explain immunosuppressive effect of cannabinoid drugs, which may be important for the pharmacological evaluation of these drugs, e.g. with respect to their use in neuroinflammatory diseases and T cell-mediated autoimmune disorders like multiple sclerosis.”

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790974/#!po=45.6522