“Recently it has been proposed that tightly regulated levels of endogenous cannabinoids play a fundamental role in early placental development.
The aim of this study was to investigate associations of three single-nucleotide polymorphisms (SNPs) in the cannabinoid 1 receptor (CNR1) gene (rs1049353, rs12720071 and rs806368) and their inferred haplotypes with pre-eclampsia, a severe pregnancy-associated condition characterized by abnormal development and remodeling of spiral decidual arteries…
This is the first study focusing on the relationship between SNPs in the CNR1 gene and pre-eclampsia risk.
Although limited by a relatively small sample size, the study indicates that rs806368 in the CNR1 gene may act as a susceptibility marker for pre-eclampsia in humans.”