“Cannabinoid receptor-2 activation plays a protective role against ischemic reperfusion injury (IRI) in various organs, and exerts a protective effect against paraquat-induced acute lung injury, while the role of CB2 in lung IRI remains unclear.
Hence, the present study was designed to explore the role of CB2 in lung IRI, and whether the PI3K pathway was involved.
The study suggested that activation of CB2 receptor plays a protective role against IR-induced lung injury through reducing inflammation in mice.
The PI3K/Akt pathway might be involved in the protective effect of CB2 receptors in lung IRI.”