“Social isolation stress (SIS) paradigm is a chronic stress procedure able to induce profound behavioral and neurochemical changes in rodents and evokes depressive and anxiety-like behaviors.
Recent studies demonstrated that the cannabinoid system plays a key role in behavioral abnormalities such as depression through different pathways; however, there is no evidence showing a relation between SIS and the cannabinoid system.
This study investigated the role of the cannabinoid system in depressive-like behavior and anxiety-like behavior of IC animals.
Our findings suggest that the cannabinoid system is involved in depressive-like behaviors induced by SIS.
We showed that activation of cannabinoid receptors (type 1 and 2) could mitigate depression-like behavior induced by SIS in a mouse model.”