“Experimental animal models of migraine have suggested the existence of interactions between the endocannabinoid system and pain mediation in migraine.
Extensive evidence has demonstrated a role for the cannabinoid-1 (CB1) receptor in antinociception.
…recent research suggests that also CB2 receptors, especially located outside the central nervous system, play a role in the perception of pain…
In this study we evaluated the role of CB2 receptors in two animal models of pain that may be relevant for migraine…
CONCLUSION:
These findings suggest that the pharmacological manipulation of the CB2 receptor may represent a potential therapeutic tool for the treatment of migraine.”