“Endocannabinoid system activity contributes to the homeostatic defense against aging and thus may counteract the progression of brain aging.
The cannabinoid type 1 (CB1) receptor activity declines with aging in the brain, which impairs neuronal network integrity and cognitive functions.
Altogether, these findings suggest that reduced CB1 signaling in CB1-KO mice leads to reduced mitophagy and abnormal mitochondrial morphology in hippocampal neurons during aging.
These mitochondrial changes might be due to the impairments in mitochondrial quality control system, which links age-related decline in CB1 activity and impaired memory.”
https://www.ncbi.nlm.nih.gov/pubmed/32294520
https://www.sciencedirect.com/science/article/abs/pii/S0361923020301386?via%3Dihub