“Cannabinoid pharmacology has proven nettlesome with issues of promiscuity a common theme among both agonists and antagonists.
One recourse is to develop allosteric ligands to modulate cannabinoid receptor signaling.
Cannabinoids have come late to the allosteric table…
In summary, three of the allosteric modulators evaluated function in a manner consistent with allosterism in a neuronal 2-AG-based model of endogenous cannabinoid signaling.”