“Most chemotherapeutic agents for the treatment of cancer can destroy tumors and arrest cancer progress but cancer treatment may damage healthy cells and tissues. Thus, new anticancer drugs from natural products are expected to play an important role in the development of more effective and safer agents to inhibit the onset of cancer… Anticancer activity of subfractions containing pure compounds of Chaga mushroom (Inonotus obliquus) extract in human cancer cells..In conclusion, the three subfractions (3β-hydroxy-lanosta-8,24-dien-21-al, inotodiol, and lanosterol) inhibited in vitro proliferation of various human cancer cell lines… 3β-hydroxy-lanosta-8,24-dien-21-al, inotodiol, and lanosterol may therefore be interesting compounds for the development of novel anticancer drugs and functional anticancer food.” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895696/
“Anti-cancer effect and structural characterization of endo-polysaccharide from cultivated mycelia of Inonotus obliquus.” http://www.ncbi.nlm.nih.gov/pubmed/16458328
“Anticancer effects of fraction isolated from fruiting bodies of Chaga medicinal mushroom, Inonotus obliquus (Pers.:Fr.) Pilát (Aphyllophoromycetideae): in vitro studies.” http://www.ncbi.nlm.nih.gov/pubmed/22135889
“Antitumor and immunomodulatory activity of water-soluble polysaccharide from Inonotus obliquus.” http://www.ncbi.nlm.nih.gov/pubmed/22840014
“Identification of Inonotus obliquus and analysis of antioxidation and antitumor activities of polysaccharides.” http://www.ncbi.nlm.nih.gov/pubmed/18795365
“Antitumor activity of water extract of a mushroom, Inonotus obliquus…” http://www.ncbi.nlm.nih.gov/pubmed/19367670
“Progress on understanding the anticancer mechanisms of medicinal mushroom: inonotus obliquus. Cancer is a leading cause of death worldwide. Recently, the demand for more effective and safer therapeutic agents for the chemoprevention of human cancer has increased. As a white rot fungus, Inonotus obliquus is valued as an edible and medicinal resource. Chemical investigations have shown that I. obliquus produces a diverse range of secondary metabolites, including phenolic compounds, melanins, and lanostane-type triterpenoids. Among these are active components for antioxidant, antitumoral, and antiviral activities and for improving human immunity against infection of pathogenic microbes…polysaccharides from I. obliquus can indirectly be involved in anticancer processes mainly via stimulating the immune system. Furthermore, the antioxidative ability of I. obliquus extracts can prevent generation of cancer cells… mechanisms underlying the anticancer influence of I. obliquus…” http://www.ncbi.nlm.nih.gov/pubmed/23679238
“In vitro antitumor activity and structure characterization of ethanol extracts from wild and cultivated Chaga medicinal mushroom, Inonotus obliquus (Pers.:Fr.) Pilát (Aphyllophoromycetideae).” http://www.ncbi.nlm.nih.gov/pubmed/22135888
“Potential anticancer properties of the water extract of Inonotus obliquus by induction of apoptosis in melanoma cells…This study showed that the water extract of Inonotus obliquus mushroom exhibited a potential anticancer activity against melanoma cells in vitro and in vivo through the inhibition of proliferation and induction of differentiation and apoptosis of cancer cells…” http://www.ncbi.nlm.nih.gov/pubmed/19041933
“Comparative study of antioxidant activity and antiproliferative effect of hot water and ethanol extracts from the mushroom Inonotus obliquus.” http://www.ncbi.nlm.nih.gov/pubmed/19147108