“Cannabinoid system is a potential target for pain control.
Cannabinoid receptor 1 (CB1) activation play a role in the analgesic effect of cannabinoids once it is expressed in primary afferent neurons.
This study investigates whether the anti-hyperalgesic effect of CB1receptor activation involves P2×3 receptor in primary afferent neurons.
Our data suggest that the analgesic effect of CB1 receptor activation is mediated by a negative modulation of the P2×3 receptor in the primary afferent neurons.”