“Schizophrenia is a neuropsychiatric disorder in which abnormalities in the prefrontal cortex lead to impaired synthesis of dopamine. It is associated with hallucination, psychosis and hearing impairments. Many susceptible genes have been identified in schizophrenia such as catechol-O-methyltransferase (COMT) and serine/threonine kinase (AKT1).

Moreover, a study based on a single family showed COMT Met allele inheritance in schizophrenic offspring. This suggested that COMT allele alteration influences susceptibility to at least some forms of psychosis…

Interestingly, according to our socio-economic survey, COMT genotype has no association with cannabis but it is strongly associated with tobacco.”

http://www.ncbi.nlm.nih.gov/pubmed/25801838

http://www.thctotalhealthcare.com/category/schizophrenia/