“Beta-caryophyllene is an abundant terpene in cannabis, cinnamon, black pepper, cloves, and citrus fruit, delivering a striking, woody-spicy, like cloves and a sweet fruity aroma.
Beta-caryophyllene is a Food and Drug Administration-approved food additive with Generally Recognized as Safe status.
Interestingly, several biologic activities have been described for beta-caryophyllene, including anti-inflammatory and analgesic effects, neuroprotection against cerebral ischemia and neuronal injury, protection of neurovascular unit against oxidative damage, glial activation and neuroinflammation and anticonvulsant effects.
In this chapter, we intend to review the beneficial effects of beta-caryophyllene in the context of psychiatric and neurological diseases. Also, we will analyze the possibility that the blood-brain-barrier may be a central target underlying the beneficial actions of beta-caryophyllene.”
https://pubmed.ncbi.nlm.nih.gov/39029971/
“Compelling evidence support the therapeutic potential of beta-caryophyllene in a broad range of conditions. Moreover, this natural compound is already in use with food and cosmetic industries. Altogether, these features may enable its application as a therapeutic adjuvant to conventional drug therapy for often difficult to treat psychiatric and neurological diseases in the near future. “
https://www.sciencedirect.com/science/article/abs/pii/S0083672924000074?via%3Dihub