“Since ancient times, plants have been used for therapeutic purposes.
Cannabis sativa has been widely used as a medicinal herb by Ayurveda and traditional Chinese medicine for centuries.
According to our in vitro and in vivo experimental models, cannabinoids are able to modulate fibrosis.
The exact mechanism underlying this effect requires further investigation, but it seems to go beyond their anti-inflammatory and immunomodulatory properties.
Based on the above observations, we aimed to investigate the role of cannabinoids in systemic sclerosis (SSc), an autoimmune disease characterized by diffuse fibrosis.
Since preclinical data on cannabinoids show their capability to modulate fibrosis, inflammation and vasodilatation, these molecules could be ideal drugs for targeting SSc.”