“Background: Acne is a common inflammatory skin disease, while cannabidiol (CBD) is a representative non-psychoactive phytocannabinoid which has been proved to exert universal anti-inflammatory properties. This study aimed to explore the effect of CBD on acne inflammation induced by Cutibacterium acnes-derived extracellular vesicles (CEVs) in keratinocytes and reveal the underlying mechanisms.
Results: The expression of inflammatory cytokines (IL-6, IL-8 and TNF-α) in CEVs-stimulated NHEKs was suppressed by CBD. CB2 receptor expression was upregulated by CBD, whereas CEVs-promoted TRPV1 expression was downregulated by CBD. AM630 reversed TNF-α levels inhibited by CBD. Capsazepine exerted an inhibitory effect on CEVs-induced inflammation and had synergistic effect with CBD. The phosphorylation of ERK1/2 and NF-κB p65 and nuclear translocation of NF-κB p65 were induced by CEVs but reduced by CBD.
Conclusion: The results indicated that CBD could inhibit inflammation induced by CEVs in NHEKs, which was mediated by activation of CB2 receptor and enhanced by the TRPV1 antagonist, through inactivation of the MAPK and NF-κB signaling pathways. CBD might be a potential novel strategy for acne treatment in the future.”
https://pubmed.ncbi.nlm.nih.gov/35982758/
“In conclusion, our results provided the evidence that CBD exerted an inhibitory effect on acne inflammation in keratinocytes induced by CEVs, which was mediated by CB2 receptor and through inactivating the MAPK and NF-κB signaling pathways. The TRPV1 antagonist Capsazepine had synergistic effect with CBD, but whether TRPV1 directly mediated the anti-inflammatory action of CBD still remains to be confirmed. Besides, the regulatory effect of CB2 receptor and TRPV1 on the MAPK and NF-κB signaling pathways in the acne model should also be further unraveled. Despite several limitations above, our study proposes the anti-acne property of CBD and a potent novel therapeutic approach for acne.”