“Pneumococcal meningitis is a life-threatening disease characterized by an acute infection affecting the pia matter, arachnoid and subarachnoid space. The intense inflammatory response is associated with a significant mortality rate and neurologic sequelae, such as, seizures, sensory-motor deficits and impairment of learning and memory.

The aim of this study was to evaluate the effects of acute and extended administration of cannabidiol on pro-inflammatory cytokines and behavioral parameters in adult Wistar rats submitted to pneumococcal meningitis.

The extended administration of cannabidiol at different doses reduced the TNF-α level in frontal cortex. Prolonged treatment with canabidiol, 10mg/kg, prevented memory impairment in rats with pneumococcal meningitis.

Although descriptive, our results demonstrate that cannabidiol has anti-inflammatory effects in pneumococcal meningitis and prevents cognitive sequel.”  https://www.ncbi.nlm.nih.gov/pubmed/23085269

“Although descriptive, our results demonstrate that chronic treatment with CBD plays an anti-inflammatory role in pneumococcal meningitis. Furthermore, it prevents cognitive damage, possibly representing a new pharmacological approach towards pneumococcal meningitis.” https://www.sciencedirect.com/science/article/pii/S0014299912008485?via%3Dihub