“Traumatic brain injury (TBI) can cause persistent challenges including problems with learning and memory.
Previous studies suggest that the activation of the cannabinoid 1 receptor after a traumatic brain injury could be beneficial.
We tested the hypothesis that posttraumatic brain injury administration of a cannabinoid 1 receptor agonist can rescue deficits in learning and memory.
Young adult male rats were subjected to a moderately severe controlled cortical impact brain injury, with a subset given postinjury i.p. injections of a cannabinoid receptor agonist.
Utilizing novel object recognition and the morris water task, we found that the brain-injured animals treated with the agonist showed a marked recovery.”
http://www.ncbi.nlm.nih.gov/pubmed/25815355
“Taken together, this study shows that the administration of a CB1R agonist after a TBI rescues deficits in learning and memory.” http://onlinelibrary.wiley.com/doi/10.1002/acn3.163/full