“Cannabinoid receptor 2 (CB2R) signaling in the brain is associated with the pathophysiology of depression.
Sickness behavior, characterized by lessened mobility, social interaction, and depressive behavior, is linked with neuroinflammation, oxidative stress, and immune system.
The present study was aimed at evaluating 1-phenylisatin (PI), a CB2R agonist, in sickness behavior.
Our data propose that acute and long-term activation of CB2R might prevent neuroinflammation and oxidative stress-associated sickness behavior.”