“Cannabinoids (CB) modulate adult hematopoietic stem and progenitor cell (HSPCs) function, however, impact on the production, expansion or migration of embryonic HSCs is currently uncharacterized.
Here, using chemical and genetic approaches targeting CB-signaling in zebrafish, we show that CB receptor (CNR) 2, but not CNR1, regulates embryonic HSC development…
Together, these data suggest CNR2-signaling optimizes the production, expansion and migration of embryonic HSCs by modulating multiple downstream signaling pathways.”