“Brain ischemia produces neuronal cell death and the recruitment of pro-inflammatory cells.
In turn, the search for neuroprotection against this type of insult has rendered results involving a beneficial role of endocannabinoid receptor agonists in the Central Nervous System.
In this work, to further elucidate the mechanisms associated to this neuroprotective effect…
Motor tests showed a progressive deterioration in motor activity in ischemic animals, which only ACEA treatment was able to counteract.
Our results suggest that CB1R may be involved in neuronal survival and in the regulation of neuroprotection during focal cerebral ischemia in mice.”