“Painful peripheral neuropathy is a dose-limiting complication of chemotherapy. Cisplatin produces a cumulative toxic effect on peripheral nerves…”
“Cannabinoid type-1 receptor reduces pain and neurotoxicity produced by chemotherapy”
“Clinically, the synthetic cannabinoid agonist nabilone reduces chemotherapy-induced pain”
“Like synthetic CB1R agonists, AEA attenuates hyperalgesia in models of neuropathic, inflammatory and tumor pain.”
“Collectively, these results suggest that pharmacological facilitation of AEA signaling is a promising strategy for attenuating cisplatin-associated sensory neuropathy.”
“Conclusion
We have shown that cisplatin produces hyperalgesia and toxicity to sensory neurons as indicated by neurochemical, morphological and functional measures. Increasing AEA signaling at CB1 receptors not only reduced the hyperalgesia but reduced the neurotoxicity of cisplatin as well. Although the mechanisms by which AEA reduce neurotoxicity remain to be resolved, the present studies underscore the dual utility in exploiting the endocannabinoid system for management of neuropathic pain produced by chemotherapy.”
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