“Cannabis has been used in medicine for thousands of years, yet its use for therapeutic purposes is still controversial. Meta-analysis of the literature has shown the effectiveness of cannabinoids only in some diseases. Researchers are particularly interested in their use in chronic pain management, which analgesic effect has been proved in many studies. A review of the literature indicates that cannabinoid preparations may be effective in the treatment of some chronic pain disorders, particularly in neuropathic pain, and should be considered as a possible therapeutic choice in the absence of a satisfactory analgesic effect with standard medications. The increasing number of countries approving cannabinoids for medical use creates an opportunity to conduct more clinical trials and collect better-quality data necessary to establish clear guidelines and consistent recommendations for specific pain disorders.”