“The potential protective effect of cannabidiol, the major non-psychotropic Cannabis constituent, was investigated against doxorubicin cardiotoxicity in rats.
Histopathological examination showed that cannabidiol ameliorated doxorubicin-induced cardiac injury.
Immunohistochemical analysis revealed that cannabidiol significantly reduced the expression of inducible nitric oxide synthase, nuclear factor-κB, Fas ligand and caspase-3, and increased the expression of survivin in cardiac tissue of doxorubicin-treated rats.
These results indicate that cannabidiol represents a potential protective agent against doxorubicin cardiac injury.”