Category Archives: Alzheimer’s Disease (AD)

Alzheimer’s disease; taking the edge off with cannabinoids?

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“Thus, cannabinoids offer a multi-faceted approach for the treatment of Alzheimer’s disease by providing neuroprotection and reducing neuroinflammation, whilst simultaneously supporting the brain’s intrinsic repair mechanisms by augmenting neurotrophin expression and enhancing neurogenesis. The evidence supporting a potential role for the cannabinoid system as a therapeutic target for the treatment of Alzheimer’s disease will be reviewed herewith.”

http://www.medicalmarijuanainc.com/index.php/alzheimer-s-disease

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190031/

Cannabidiol and other cannabinoids reduce microglial activation in vitro and in vivo: relevance to Alzheimer’s disease

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“CBD is able to modulate microglial cell function in vitro and induce beneficial effects in an in vivo model of AD. Given that CBD lacks psychoactivity, it may represent a novel therapeutic approach for this neurological disease.”

http://www.medicalmarijuanainc.com/index.php/alzheimer-s-disease

Cannabidiol: from an inactive cannabinoid to a drug with wide spectrum of action

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“These studies have suggested a wide range of possible therapeutic effects of cannabidiol on several conditions, including Parkinson’s disease, Alzheimer’s disease, cerebral ischemia, diabetes, rheumatoid arthritis, other inflammatory diseases, nausea and cancer.”

http://www.medicalmarijuanainc.com/index.php/alzheimer-s-disease

Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on beta-amyloid-induced toxicity in PC12 cells

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“Our results indicate that cannabidiol exerts a combination of neuroprotective, anti-oxidative and anti-apoptotic effects against beta-amyloid peptide toxicity, and that inhibition of caspase 3 appearance from its inactive precursor, pro-caspase 3, by cannabidiol is involved in the signalling pathway for this neuroprotection.”

http://www.ncbi.nlm.nih.gov/pubmed/15030397 

Marijuana Slows Alzheimer’s Decline

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“the investigators confirmed that cannabinoids counteracted the activation of microglia and thus reduced inflammation.  These findings that cannabinoids work both to prevent inflammation and to protect the brain may set the stage for their use as a therapeutic approach for Alzheimer’s disease, de Ceballos said.”

http://www.mapinc.org/drugnews/v05/n307/a10.html