Use of cannabinoid receptor agonists in cancer therapy as palliative and curative agents.

Posted on October 22, 2012 by David

“Cannabinoids (the active components of Cannabis sativa) and their derivatives have received renewed interest in recent years due to their diverse pharmacological activities. In particular, cannabinoids offer potential applications as anti-tumour drugs, based on the ability of some members of this class of compounds to limit cell proliferation and to induce tumour-selective cell death. Although synthetic cannabinoids may have pro-tumour effects in vivo due to their immunosuppressive properties, predominantly inhibitory effects on tumour growth and migration, angiogenesis, metastasis, and also inflammation have been described. Emerging evidence suggests that agonists of cannabinoid receptors expressed by tumour cells may offer a novel strategy to treat cancer. In this chapter we review the more recent results generating interest in the field of cannabinoids and cancer, and provide novel suggestions for the development, exploration and use of cannabinoid agonists for cancer therapy, not only as palliative but also as curative drugs.” https://www.ncbi.nlm.nih.gov/pubmed/19285265

“Use of cannabinoid receptor agonists in cancer therapy as palliative and curative agents” http://www.bprcem.com/article/S1521-690X(09)00005-0/abstract

Cannabis-derived substances in cancer therapy–an emerging anti-inflammatory role for the cannabinoids.

Posted on October 22, 2012 by David

“Cannabinoids, the active components of the cannabis plant, have some clinical merit both as an anti-emetic and appetite stimulant in cachexic patients. Recently, interest in developing cannabinoids as therapies has increased following reports that they possess anti-tumour properties.

Research into cannabinoids as anti-cancer agents is in its infancy, and has mainly focussed on the pro-apoptotic effects of this class of agent. Impressive anti-cancer activities have been reported; actions that are mediated in large part by disruptions to ubiquitous signalling pathways such as ERK and PI3-K. However, recent developments have highlighted a putative role for cannabinoids as anti-inflammatory agents. Chronic inflammation has been associated with neoplasia for sometime, and as a consequence, reducing inflammation as a way of impacting cancer presents a new role for these compounds.

This article reviews the ever-changing relationship between cannabinoids and cancer, and updates our understanding of this class of agent. Furthermore, the relationship between chronic inflammation and cancer, and how cannabinoids can impact this relationship will be described.”

http://www.ncbi.nlm.nih.gov/pubmed/20925645

Cannabinoid receptor ligands as potential anticancer agents–high hopes for new therapies?

Posted on October 22, 2012 by David

“OBJECTIVES:

The endocannabinoid system is an endogenous lipid signalling network comprising arachidonic-acid-derived ligands, cannabinoid (CB) receptors, transporters and endocannabinoid degrading enzymes. The CB(1) receptor is predominantly expressed in neurons but is also co-expressed with the CB(2) receptor in peripheral tissues. In recent years, CB receptor ligands, including Delta(9)-tetrahydrocannabinol, have been proposed as potential anticancer agents.

KEY FINDINGS:

This review critically discusses the pharmacology of CB receptor activation as a novel therapeutic anticancer strategy in terms of ligand selectivity, tissue specificity and potency. Intriguingly, antitumour effects mediated by cannabinoids are not confined to inhibition of cancer cell proliferation; cannabinoids also reduce angiogenesis, cell migration and metastasis, inhibit carcinogenesis and attenuate inflammatory processes. In the last decade several new selective CB(1) and CB(2) receptor agents have been described, but most studies in the area of cancer research have used non-selective CB ligands. Moreover, many of these ligands exert prominent CB receptor-independent pharmacological effects, such as activation of the G-protein-coupled receptor GPR55, peroxisome proliferator-activated receptor gamma and the transient receptor potential vanilloid channels.

SUMMARY:

The role of the endocannabinoid system in tumourigenesis is still poorly understood and the molecular mechanisms of cannabinoid anticancer action need to be elucidated. The development of CB(2)-selective anticancer agents could be advantageous in light of the unwanted central effects exerted by CB(1) receptor ligands. Probably the most interesting question is whether cannabinoids could be useful in chemoprevention or in combination with established chemotherapeutic agents.”

http://www.ncbi.nlm.nih.gov/pubmed/19589225

Is The NFL’s Campaign For Breast Cancer Awareness Really A Scam?

Posted on October 22, 2012 by David

“October is breast cancer awareness month, and with that, the NFL has decided to pitch in to raise both money and awareness for breast cancer research.

But how much of that money is actually going to find a cure for breast cancer? According to a report, not very much.

Every October, NFL teams sport pink shoes, gloves, towels, hats and shirts, all designed to raise money and awareness. The NFL’s fundraising effort is multifaceted: There’s the off-field auction of autographed NFL paraphernalia and there’s the NFL online store that entices shoppers to purchase officially licensed NFL breast cancer gear.

A report from Business Insider revealed that 5% of purchases of officially licensed gear go back to the American Cancer Society. The rest of the cash goes directly into the NFL’s pockets.

Through four seasons of this pink initiative, the NFL has raised just $3 million for breast cancer research. To put that into perspective, the NFL made $9.5 billion last year.”

http://chicago.cbslocal.com/2012/10/11/is-the-nfls-campaign-against-breast-cancer-really-a-scam/

The NFL’s Campaign Against Breast Cancer Is a Total Scam

Posted on October 22, 2012 by David

By Erin Gloria Ryan

“Have you noticed that during the month of October, the NFL suddenly becomes intensely concerned with making sure you’re aware of breast cancer? Pink jerseys! Huge Ass Pink Ribbons at midfield! Pink motherfucking cleats! Fans interested in aware-ing on their own can even click on over to the NFL’s store and purchase ugly pink crap of their own under the assumption that their good intentions will actually contribute to the fight against cancer. Well, I hate to burst your Pepto Bismo Pink bubble, wearers of dangly earrings that contain both ribbons and tiny footballs, but you’ve been had — the NFL’s Breast Cancer Awareness Month campaign does raise itsy bitsy amounts of money for the fight against cancer, but the amount of money it raises pales in comparison to the amount of money it raises for billionaire NFL owners.

The NFL claims that its pink philanthropy efforts “support the fight against breast cancer” by “promoting awareness” and providing funds to the American Cancer Society. But what they’re mostly promoting is, uh, buying NFL gear, the profits from which are overwhelmingly pocketed by the NFL.

According to Business Insider, the NFL’s October Breast Cancer Awareness Month fundraising effort is multi-pronged. There’s the on-field onslaught of pink (AWARENESS), the off-field auction of autographed or otherwise noteworthy NFL paraphernalia (MONEY FOR THE CURE!), and the part of the NFL store that entices shoppers to purchase officially licensed NFL breast cancer gear, a portion of which goes to FINDING A CURE. According to the League, 100% of the proceeds from the specialty auction go to the American Cancer Society, but the total percentage of purchases of officially licensed gear that actually goes to FINDING A CURE is actually kind of pathetic — 5%. If you want to look at this cynically, in a way, the on-field wearin’ o’ the pink serves as an ad to direct consumers to purchase pink fan items.

BUT WAIT, you might say, AT LEAST THEY’RE DOING SOMETHING. And 5% is still something! Well, kind of. As BI pointed out, if NFL products are sold at a 100% markup and only 5% of sale proceeds go to the American Cancer Society, then the NFL is pocketing 90% of sales of Breast Cancer Awareness products, many of which would not be purchased if they didn’t come with a promise that consumers were “helping.” And, more perspective: while the American Cancer Society isn’t, say, Komen, they still don’t use 100% of the money they receive to “fight” breast cancer. Only 70% of donations taken in by the organization go toward cancer research. So, if you spend $10 on pink stink from the NFL, only about 35 cents is going to finding a cure for breast cancer. And $4.50 goes right back to the NFL, where I like to imagine that it’s spent on gas for a Lake Minnetonka pleasure cruise. For the cure.

But what about awareness?! Surely the NFL is helping keep people aware and alert and vigilant that at any moment, breast cancer could be lurking around a corner in a dark alley waiting with a hot pink switchblade to steal your purse and boobs. The thing about awareness is that it’s all but impossible to quantify — and everyone knows about breast cancer. If you asked 100 people if they’re aware that breast cancer is a thing and that it’s almost impossible to predict and most often affects women, I’d bet that most of them would nod before slowly backing away from you. Breast cancer awareness is so ubiquitous that if deadly diseases attended the same high school, breast cancer would probably be voted prom queen. The “awareness” that comes from the NFL’s sales of pink branded items doesn’t justify the extent to which the league is taking advantage of consumers’ good intentions to pad their wallets. Even if no NFL player ever touched another pink thing again, Americans would go right on being aware of the disease. Unless the Buffalo Jills or New Orleans Saintsations cheerleaders are holding up signs that show women how to give themselves breast self-exams or tickets come with 5 page printouts of places low income women can obtain breast health screening for low or no cost, the type of awareness the NFL is providing is useless, vague garbage.

Since the program’s inception four years ago, the NFL has raised $3 million for breast cancer. In 2009, the League made $8.5 billion. Last year, they made $9.5 billion. Commissioner Roger Goodell has set a revenue goal of $25 billion per year by the year 2027. A million per year out of between $8.5 and $9.5 billion in revenues? Pardon me while I don’t slobber all over the NFL’s pink-drenched marketing campaign.

Want to cure breast cancer? Give directly to an organization that cures breast cancer, or to an advocacy group that seeks actual cures, not marketing and corporate profits. Besides, wearing those horrid pink NFL breast cancer rain boots actually causes cancer. Of the eyes.”

http://jezebel.com/5950971/the-nfls-campaign-against-breast-cancer-is-a-total-scam

Is the pink ribbon campaign a scam?

Posted on October 22, 2012 by David

“The pink ribbon has become synonymous with solidarity for women who battle breast cancer. After all, a diagnosis of breast cancer changes the life of the diagnosed and the lives of all those involved — many times for the worse.

But, did you ever stop to think about what the pink ribbon campaign is all about? Is it really meant to bring “awareness” to breast cancer? Hasn’t everyone heard of breast cancer? Some have questioned the motives of those who stand behind those pretty pink ribbons.

Some have suggested that Breast Cancer Awareness month can be seen as a push for women to be corralled into the mammography suite so they can await their breast cancer diagnosis when the mammography is complete.

The science behind mammography is clear. Mammography does more harm than good.

Yes, the concept seems harsh. After all, most people who wear pink ribbons are innocent. They just go along with the rest. It’s a chance to show that they support the cause, whatever that is.

The pink ribbon campaign, however, is not completely innocent. Take for example this questionable involvement in the pink ribbon campaign. In October 2010, KFC filled and sold the “Bucket for the Cure,” donating 50 cents to breast cancer for each bucket sold. If KFC had a real interest for preventing breast cancer or for finding its cure, wouldn’t they close their doors forever? After all, the Physicians Committee for Responsible Medicine (PCRM) sued KFC for not disclosing to its customers that the chicken sold at KFC contained a dangerous carcinogen. “KFC should post warnings because its aggressively marketed new product harbors a chemical that increases the risk of breast cancer, prostate cancer, and other forms of this lethal disease,” commented Dr. Neal Barnard, of PCRM.

While some participants in the pink ribbon campaign do send raised funds to breast cancer charities, such as Komen for the Cure, others do not follow through with contributions. The Better Business Bureau has issued warnings to consumers regarding this shell game.

Pink Ribbons have hope. On the other hand, the entire breast cancer awareness initiative would be worthwhile if we continued to raise money to advertise the information that we already have about breast cancer prevention: diet, exercise, stress management prevent breast cancer. Why is it that people do not know that eating a low-fat whole plant foods diet is the single most important thing you can do to prevent breast cancer? Why don’t breast cancer organizations teach what we already know instead of continuing to look for a cure that comes in an expensive pill, treatment, or surgery?

Who’s benefiting here, anyway?”

Marijuana: A cure for breast cancer

Posted on October 22, 2012 by David

“Cannabis, or rather marijuana, has been known as an illegal drug that is used primarily to get “high” and has no other value. This is what many people have thought of marijuana for at least the last 75 years.

Over the years, numerous research studies have been conducted on cannabis and there were discussions about its medicinal benefits for cancer treatment; however, because this is an illegal drug, much of the research hasn’t been known to the average citizen.

Within the last 10-15 years, the interest in cannabis as a possible cure for cancer has increased substantially. In addition, there has been an increase in citizens demanding the ability to use medicinal cannabis as a treatment for their disease or illness.

These recent studies have shown that cannabis may be a cure for cancer. One study
conducted in 2007 by the California Pacific Medical Center in San Francisco, CA determined that a compound in cannabis called “Cannabidiol” was effective at inhibiting aggressive breast cancers. It was discovered that a certain “key gene caused breast cancer to spread and that cannabidiol could inhibit that aggressive gene by stopping the spread of the tumor cells”. This study was published in the Washington Post and Science Daily
as well.

Unfortunately, cannabis is a schedule 1 drug which means that additional research and FDA approval would be required for cannabis to be used for the treatment of cancer. It would require the removal of cannabis as a schedule 1 drug.

There is information that may suggest the U.S. Government and the Drug Enforcement Agency (DEA) may have already known about the benefits of cannabis to treat cancer. The National Cancer Institute published a study in 1974. Due to federal law, no further studies were conducted until the 1990’s. All research conducted since then has been via test tube and animal studies.

In an October 2003 review on test tube and animal research indicated that cannabinoids inhibit tumors of the lung, uterus, skin, breast, prostate, and brain. Cannabis is also known to provide nausea relief to cancer patients and to increase appetite.

Medicinal cannabis may be the cure for cancer. Additional research is needed; however, it may require reclassifying cannabis in order to obtain government approval.”

http://www.examiner.com/article/marijuana-a-cure-for-breast-cancer

Marijuana compound could help fight breast cancer – ABC News

Posted on October 20, 2012 by David

“There may be a new weapon in the fight against aggressive forms of breast cancer in the future, and it comes from an unlikely source: Marijuana. Researchers at California Pacific Medical Center in San Francisco believe a compound in marijuana may help.

The research funded by the California Breast Cancer Research Program builds on more than a decade of studies involving the genes responsible for the spread of cancer. Now scientists have found at the cellular level, a compound in cannabis inhibits the gene that controls the spread of cancer.

“The problem is not the cancer itself, the problem is the spread of the cancer,” said cancer researcher Yvez Desprez, Ph.D.

Cancer researcher Pierre Desprez points to the gene ID-1 as the trigger.

“When this type of gene is expressed, the cells basically go crazy and they’re very aggressive and they metastasize everywhere in the body,” said Desprez.

“We could expect that if we create really effective inhibitors against it, we could potentially treat many types of aggressive cancers,” said cancer researcher Sean McAllister, Ph.D.

Their research in breast cancer cell lines focused on using a non-toxic compound in cannabis to target the ID-1 gene.

“What we found was cannabidiol is a particularly good inhibitor of this gene that’s responsible for the ability of cancer cells to become very aggressive,” said McAllister.”

http://abclocal.go.com/kgo/story?section=news/health&id=5771385

Scientists believe marijuana compound could fight cancer

Posted on October 20, 2012 by David

“Scientists in California believe they may have discovered a compound in marijuana that can reduce the aggressiveness of some forms of cancer.

The San Francisco Gate reports on the data that has been years in the making. While marijuana has been shown to help reduce nausea and pain in cancer patients, scientists believe that a compound in marijuana has the ability to “turn off” the activity of a gene responsible for metastasis in breast and other types of cancers.

The research team is working out of San Francisco’s California Pacific Medical Center Research Institute and have been working for years on the study. The compound they’re focused on, called cannabidiol, does not produce the psychotropic high associated with marijuana.

Last year, the team published a small study showing the positive effects of cannabidiol on mice. New data is about to be released that expands upon the previous results that the researchers hope will help propel the study even further.

“The preclinical trial data is very strong, and there’s no toxicity. There’s really a lot of research to move ahead with and to get people excited,” said Sean McAllister, who is working alongside scientist Pierre Desprez in the study.

Desprez and McAllister believe that their merging of separate areas of study was serendipitous.

Desprez had been studying the protein ID-1, which he found to play an important role in how cancer could spread. McAllister, on the other hand, was focused on studying anabolic steroids in drug abuse. He soon became focused on with the role non-psychotropic cannabidiol, or CBD, interacts with cancer.

McAllister, after hearing an internal seminar from Desprez on his studies of ID-1, came up with the question “How effective would cannabidiol be on targeting metastatic cancer cells?”

The two then teamed up, with Desprez armed with ID-1 cancer-causing protein, and McAllister with CBD, his cancer-fighting compound.

For their experimentation, the doctors exposed ID-1 to CBD in a petri dish. In a shocking result, the ID-1, the cancer-causing protein, reverted to a normal state and stopped acting “crazy.”

“We thought we did the experiment the wrong way,” McAllister said of the overwhelming results.

However, their results proved to be consisted.

“I told Sean, ‘Maybe your drug is working through my gene,’ ” Desprez said.

What the researchers have discovered thus far in their research is that CBD turns off the overexpression of ID-1, which prevents it from traveling to foreign tissues. Thus, the metastasization – cancer’s fatal ability – is blocked.

In the wake of their positive results, the doctors were forced to emphasize that the CBD will only work in the presence of high levels of ID-1 and these do not include all cancerous tumors but, rather, aggressive, metastatic cells. High levels have been found in leukemia, colorectal, pancreatic, lung, ovarian, brain and other cancers.”
Read more: http://www.irishcentral.com/news/Scientists-believe-marijuana-compound-could-fight-cancer-170689736.html#ixzz29rQbc2oS

Can Cannabidiol (CBD) Fight Metastatic Cancer? According to the latest research the answer is yes. Important news for Medical Marijuana, Inc.’s new line of high concentrate CBD health and wellness products.

Posted on October 20, 2012 by David

“(OTC: MJNA), a leading hemp industry innovator, is pleased to report on a September 18 San Francisco Chronicle Article, “Pot compound seen as tool against cancer.” The article states that scientists at California Pacific Medical Center who have been researching marijuana’s compounds for the 20 years have found that Cannabidiol, or CBD, has the ability to “turn off” the DNA that causes “breast and other types of cancers” to metastasize. CBD is the second-most abundant cannabinoid within marijuana, but does not cause the psychotropic high of THC.

As stated in the article: “We started by researching breast cancer,” said scientist Pierre Desprez. “But now we’ve found that Cannabidiol works with many kinds of aggressive cancers–brain, prostate–any kind in which these high levels of ID-1 are present.” Desprez said he is hopeful clinical trials will begin immediately. He currently has grant funding through the National Institutes of Health, Susan G. Komen for the Cure, the U.S. Department of Defense and the California Breast Cancer Research Program.

As previously announced in the MJNA press release dated September 5, MJNA portfolio company, Red Dice Holdings, recently launched its Hemp-based high concentrate CBD health and wellness products, Dixie X, for over-the-counter sales. These Cannabidiol products represent the highest strength of CBD products on the market today, and this same concentrate will soon be used to launch the CanChew Biotechnologies line of CBD-enriched chewing gum. Click here for recent production news from PhytoSphere. Dixie X can currently be purchased in over 100 retail locations in Colorado, Arizona and New Mexico as well as on-line by anyone living in the U.S.

In short, MJNA and its portfolio company, PhytoSphere Systems, currently produces non-THC, high quality CBD enriched Hemp oil that according to this story, may fight the most aggressive forms of cancers we know of today.

Studies, such as those in this article and at Project CBD, have continually shown that these non-psychoactive CBD wellness products provide powerful relief for pain and anxiety sufferers, but without the euphoric effects provided by THC. The CBD health and wellness industry is estimated by MJNA to be a $5 billion market.”

http://www.cnbc.com/id/49117540/Can_Cannabidiol_CBD_Fight_Metastatic_Cancer_According_to_the_latest_research_the_answer_is_yes_Important_news_for_Medical_Marijuana_Inc_s_new_line_of_high_concentrate_CBD_health_and_wellness_products

www.thctotalhealthcare.com

Category Archives: Breast Cancer

Use of cannabinoid receptor agonists in cancer therapy as palliative and curative agents.

“Use of cannabinoid receptor agonists in cancer therapy as palliative and curative agents” http://www.bprcem.com/article/S1521-690X(09)00005-0/abstract

Cannabis-derived substances in cancer therapy–an emerging anti-inflammatory role for the cannabinoids.

“Cannabinoids, the active components of the cannabis plant, have some clinical merit both as an anti-emetic and appetite stimulant in cachexic patients. Recently, interest in developing cannabinoids as therapies has increased following reports that they possess anti-tumour properties.

This article reviews the ever-changing relationship between cannabinoids and cancer, and updates our understanding of this class of agent. Furthermore, the relationship between chronic inflammation and cancer, and how cannabinoids can impact this relationship will be described.”

Cannabinoid receptor ligands as potential anticancer agents–high hopes for new therapies?

“OBJECTIVES:

KEY FINDINGS:

SUMMARY:

Is The NFL’s Campaign For Breast Cancer Awareness Really A Scam?

The NFL’s Campaign Against Breast Cancer Is a Total Scam

Is the pink ribbon campaign a scam?

Marijuana: A cure for breast cancer

Marijuana compound could help fight breast cancer – ABC News

Scientists believe marijuana compound could fight cancer

Can Cannabidiol (CBD) Fight Metastatic Cancer? According to the latest research the answer is yes. Important news for Medical Marijuana, Inc.’s new line of high concentrate CBD health and wellness products.