Category Archives: Diabetes

Smoking cannabis ‘could help prevent diabetes’

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“Smoking cannabis may help prevent diabetes, a new study has suggested.

Researchers found that regular users of the Class B drug had significantly lower levels of insulin after fasting – a sign of increased protected against diabetes. They also had reduced insulin resistance.

The results, reported in the American Journal of Medicine, showed current users had 16 per cent lower fasting insulin levels than participants who reported never having used marijuana.

The findings raise the possibility treatments for diabetes could be developed based on the active ingredient of cannabis, commonly known as THC.

Large waist measurements are also linked to diabetes risk and the study revealed significant associations between marijuana use and smaller waists.

Lead researcher Murray A. Mittleman, of the Cardiovascular Epidemiology Research Unit at the Beth Israel Deaconess Medical Center, Boston, said it was the first study ‘to investigate the relationship between marijuana use and fasting insulin, glucose, and insulin resistance’, The Albany Tribune reported.

But Joseph Alpert, professor of medicine at the University of Arizona College of Medicine, Tucson, and editor in chief of the American Journal of Medicine, said: ‘We desperately need a great deal more basic and clinical research into the short and long term effects of marijuana in a variety of clinical settings such as cancer diabetes and frailty of the elderly.’

Researchers studied data from 4,657 patients who completed a drug use questionnaire.

The use of so-called ‘medical marijuana’ is growing in the US where several states allow it.”

http://metro.co.uk/2013/05/15/cannabis-could-combat-diabetes-study-shows-3759797/

Marijuana Users Are Better at Controlling Their Blood Sugar

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“Individuals who either smoke or ingest marijuana on a fairly regular basis have a better blood sugar control than people who are non-users, a study recently published in The American Journal of Medicine suggests.

The findings of this study are based on data collected while looking into the medical records of 4,657 people who had completed a drug use questionnaire as part of a research carried out by the National Health and Nutrition Survey between 2005 and 2010…

 “Previous epidemiologic studies have found lower prevalence rates of obesity and diabetes mellitus in marijuana users compared to people who have never used marijuana, suggesting a relationship between cannabinoids and peripheral metabolic processes, but ours is the first study to investigate the relationship between marijuana use and fasting insulin, glucose, and insulin resistance,” lead researcher Murray A. Mittleman commented on the findings of this investigation.”

Read more: http://news.softpedia.com/news/Marijuana-Users-Are-Better-at-Controlling-Their-Blood-Sugar-353358.shtml

Marijuana Smokers Found to Have Lower Risk of Diabetes, Research

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Marijuana Smokers Found to Have Lower Risk of Diabetes, Research

“A new research has found that the people who smoke cannabis are having lower risk of suffering from diabetes. The researchers have said that the reason behind the same is that the people using marijuana have lower levels of insulin in blood.

This means that the blood sugar control is better in them. The link between cannabis and diabetes control is yet to be established. If it happens, a new development can be expected to treat the patients with the condition using the plant’s compound active ingredient, tetrahydrocannabinol, or THC.

The study was published in the American Journal of Medicine. It asserted that the people who consumed cannabis had 16% lower fasting of the insulin levels in comparison to those who had never smoked marijuana.

Also, the people using the drug were found to have lower waist circumference. Studies have found large waist circumference linked to diabetes risk.

Usually, marijuana is consumed by the cancer patients and others with conditions like multiple sclerosis. Medical form of the drug is legal for use in the 18 US states and most of the Americans want it to be legalized.

The findings were based on questionnaire answered by about 4,657 patients and the data derived from the National Health and Nutrition Survey between 2005 and 2010.”

http://frenchtribune.com/teneur/1318085-marijuana-smokers-found-have-lower-risk-diabetes-research

Scientist: Marijuana May Treat Diabetes – Fox News

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“Cannabis plant extracts could potentially form the basic ingredients for a market-leading diabetes drug, the scientist who developed a former world-beating treatment for the condition believes…

“There really have been relatively few developments in finding new diabetes drug treatments… This new approach might be more productive in answering the unmet clinical need.””

Read more: http://www.foxnews.com/story/0,2933,526853,00.html

 

Marijuana Users Have Better Blood Sugar Control: Study

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“Regular marijuana use has a positive effect on diabetic control, say researchers. They found that current marijuana users had significantly lower fasting insulin and were less likely to be insulin resistant, even after excluding patients with a diagnosis of diabetes mellitus. Their findings are reported in the current issue of The American Journal of Medicine.
 
Marijuana (Cannabis sativa) has been used for centuries to relieve pain, improve mood, and increase appetite. Outlawed in the United States in 1937, its social use continues to increase and public opinion is swinging in favor of the medicinal use of marijuana…”
 

Cannabis linked to prevention of diabetes

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“Regular users of the drug found to have lower levels of insulin after fasting, research shows. Smoking cannabis may prevent the development of diabetes, one of the most rapidly rising chronic disorders in the world.

If the link is proved, it could lead to the development of treatments based on the active ingredient of cannabis, tetrahydrocannabinol (THC), without its intoxicating effects.”

Read more: http://www.independent.co.uk/life-style/health-and-families/health-news/cannabis-linked-to-prevention-of-diabetes-8616314.html

The role of the pancreatic endocannabinoid system in glucose metabolism.

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“The endogenous cannabinoid system participates in the regulation of energy homeostasis, and this fact led to the identification of a new group of therapeutic agents for complicated obesity and diabetes. Cannabinoid receptor antagonists are now realities in clinical practice. The use of such antagonists for reducing body weight gain, lowering cholesterol and improving glucose homeostasis is based on the ability of the endocannabinoids to coordinately regulate energy homeostasis by interacting with central and peripheral targets, including adipose tissue, muscle, liver and endocrine pancreas. In this review we will analyse the presence of this system in the main cell types of the islets of Langerhans, as well as the physiological relevance of the endocannabinoids and parent acylethanolamides in hormone secretion and glucose homeostasis. We will also analyse the impact that these findings may have in clinical practice and the potential outcome of new therapeutic strategies for modulating glucose homeostasis and insulin/glucagon secretion.”

http://www.ncbi.nlm.nih.gov/pubmed/19285263

Presence of functional cannabinoid receptors in human endocrine pancreas.

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“We examined the presence of functional cannabinoid receptors 1 and 2 (CB1, CB2) in isolated human islets, phenotyped the cells producing cannabinoid receptors and analysed the actions of selective cannabinoid receptor agonists on insulin, glucagon and somatostatin secretion in vitro. We also described the localisation on islet cells of: (1) the endocannabinoid-producing enzymes N-acyl-phosphatidyl ethanolamine-hydrolysing phospholipase D and diacylglycerol lipase; and (2) the endocannabinoid-degrading enzymes fatty acid amidohydrolase and monoacyl glycerol lipase.

RESULTS:

Human islets of Langerhans expressed CB1 and CB2 (also known as CNR1 and CNR2) mRNA and CB1 and CB2 proteins, and also the machinery involved in synthesis and degradation of 2-AG (the most abundant endocannabinoid, levels of which were modulated by glucose). Immunofluorescence revealed that CB1 was densely located in glucagon-secreting alpha cells and less so in insulin-secreting beta cells. CB2 was densely present in somatostatin-secreting delta cells, but absent in alpha and beta cells. In vitro experiments revealed that CB1 stimulation enhanced insulin and glucagon secretion, while CB2 agonism lowered glucose-dependent insulin secretion, showing these cannabinoid receptors to be functional.

CONCLUSIONS/INTERPRETATION:

Together, these results suggest a role for endogenous endocannabinoid signalling in regulation of endocrine secretion in the human pancreas.”

http://www.ncbi.nlm.nih.gov/pubmed/18092149

Regulation, function, and dysregulation of endocannabinoids in models of adipose and beta-pancreatic cells and in obesity and hyperglycemia.

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“Cannabinoid CB(1) receptor blockade decreases weight and hyperinsulinemia in obese animals and humans in a way greatly independent from food intake.

The objective of this study was to investigate the regulation and function of the endocannabinoid system in adipocytes and pancreatic beta-cells.

Endocannabinoid enzyme and adipocyte protein expression, and endocannabinoid and insulin levels were measured.

RESULTS:

Endocannabinoids are present in adipocytes with levels peaking before differentiation, and in RIN-m5F beta-cells, where they are under the negative control of insulin. Chronic treatment of adipocytes with insulin is accompanied by permanently elevated endocannabinoid signaling, whereas culturing of RIN-m5F beta-cells in high glucose transforms insulin down-regulation of endocannabinoid levels into up-regulation. Epididymal fat and pancreas from mice with diet-induced obesity contain higher endocannabinoid levels than lean mice. Patients with obesity or hyperglycemia caused by type 2 diabetes exhibit higher concentrations of endocannabinoids in visceral fat or serum, respectively, than the corresponding controls. CB(1) receptor stimulation increases lipid droplets and decreases adiponectin expression in adipocytes, and it increases intracellular calcium and insulin release in RIN-m5F beta-cells kept in high glucose.

CONCLUSIONS:

Peripheral endocannabinoid overactivity might explain why CB(1) blockers cause weight-loss independent reduction of lipogenesis, of hypoadiponectinemia, and of hyperinsulinemia in obese animals and humans.”

http://jcem.endojournals.org/content/91/8/3171.long

Cannabidiol as an Emergent Therapeutic Strategy for Lessening the Impact of Inflammation on Oxidative Stress

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Figure 1

“Growing evidence suggests that the endocannabinoid system, which includes the CB1 and CB2 G protein-coupled receptors and their endogenous lipid ligands, may be an area that is ripe for therapeutic exploitation. In this context, the related nonpsychotropic cannabinoid cannabidiol, which may interact with the endocannabinoid system, but has actions that are distinct, offers promise as a prototype for anti-inflammatory drug development.

This review discusses recent studies suggesting that cannabidiol may have utility in treating a number of human diseases and disorders now known to involve activation of the immune system and associated oxidative stress, as a contributor to their etiology and progression. These include rheumatoid arthritis, types I and II diabetes, atherosclerosis, Alzheimer’s disease, hypertension, the metabolic syndrome, ischemia-reperfusion injury, depression, and neuropathic pain.

Cannabidiol (CBD) is the major nonpsychotropic cannabinoid compound derived from the plant Cannabis sativa, commonly known as marijuana…

Conclusions

Inflammation and oxidative stress are intimately involved in the genesis of many human diseases. Unraveling that relationship therapeutically has proven challenging, in part because inflammation and oxidative stress “feed off” each other. However, CBD would seem to be a promising starting point for further drug development given its anti-oxidant (although relatively modest) and anti-inflammatory actions on immune cells, such as macrophages and microglia. CBD also has the advantage of not having psychotropic side effects. Studies on models of human diseases support the idea that CBD attenuates inflammation far beyond its antioxidant properties, for example, by targeting inflammation-related intracellular signaling events. The details on how CBD targets inflammatory signaling remain to be defined.

The therapeutic utility of CBD is a relatively new area of investigation that portends new discoveries on the interplay between inflammation and oxidative stress, a relationship that underlies tissue and organ damage in many human diseases.”

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3085542/