“Epilepsy is the most prevalent neurological disease and is characterised by recurrent seizures. Here we investigate: (i) the anticonvulsant profiles of cannabis-derived botanical drug substances (BDS) rich in cannabidivarin (CBDV) and containing cannabidiol (CBD) in acute in vivo seizure models and (ii) the binding of CBDV BDSs and their components at cannabinoid CB1 receptors.
CBDV BDSs exerted significant anticonvulsant effects in three models of seizure that were not mediated by the CB1 cannabinoid receptor, and were of comparable efficacy to purified CBDV.
These findings strongly support the further clinical development of CBDV BDSs for treatment of epilepsy.”
“Cannabidivarin is anticonvulsant in mouse and rat… These results indicate that CBDV is an effective anticonvulsant in a broad range of seizure models.” http://www.ncbi.nlm.nih.gov/pubmed/22970845
“Drugs that modulate the endocannabinoid system and endocannabinoids typically play an anticonvulsant role although some proconvulsant effects have been reported both in humans and animal models.
This study aims to characterize the role of cannabinoids in specific areas of the cortico-thalamic network involved in oscillations that underlie seizures in a genetic animal model of absence epilepsy, the WAG/Rij rat.
These results, together with previous reports, support therapeutic potential for endocannabinoid system modulators in absence epilepsy and highlight that attenuated endocannabinergic function may contribute to the generation and maintenance of seizures. Furthermore, the entire cortico-thalamic network responds to cannabinoid treatment, indicating that in all areas considered, CB receptor activation inhibits the pathological synchronization that subserves absence seizures.
In conclusion, our result might be useful for the identification of future drug therapies in absence epilepsy.”
“Six-year-old Charlotte Figi, a picture of precious in her “Gatsby”-style bob and blue toenails, stands patiently as her mother reaches up her dress to change her out of her soiled Pull-Ups.”
A collaboration between a UK research team and international medicine manufacturers may lead to a ‘milestone’ treatment for epilepsy. This treatment appears more bearable than current epilepsy medicines – and is based on cannabis.
A research team at the University of Reading performed the research, which was recently published in The British Journal of Pharmacology. Their research explored the use of cannibidivarin – a natural chemical called a ‘cannabinoid’ from the cannabis plant.
Cannibidivarin does not have psychoactive properties (anyone taking a drug based on this chemical will not feel ‘high’ as a result). It appears to reduce seizure frequency in laboratory animals with epilepsy and has fewer side-effects than traditional epilepsy medicines. The new drug can also be safely combined with regular medications.
Lead study author, Dr Ben Whalley, said: “This is an enormously exciting milestone in our investigations into non-psychoactive elements of cannabis as treatments for epilepsy. Our work has highlighted the potential for a solution based on cannabinoid science. It has shown that cannabidivarin is the most effective and best tolerated anticonvulsant plant cannabinoid investigated to date.””
“VCU study is first to test anticonvulsant potential of marijuana and brain recurrent seizures.
Ingredients in marijuana and the cannabinoid receptor protein produced naturally in the body to regulate the central nervous system and other bodily functions play a critical role in controlling spontaneous seizures in epilepsy, according to a new study by researchers at Virginia Commonwealth University.
The study, the first to look at marijuana and the brain’s cannabinoid system in live animals with spontaneous, recurrent seizures, suggests new avenues that researchers can explore in their search for more-effective drugs to treat epileptic patients who don’t respond to today’s anticonvulsant medications or surgery.
The results appear in the Oct. 1 issue of the Journal of Pharmacology and Experimental Therapeutics.
“Although marijuana is illegal in the United States, individuals both here and abroad report that marijuana has been therapeutic for them in the treatment of a variety of ailments, including epilepsy,” says Dr. Robert J. DeLorenzo, professor of neurology in the VCU School of Medicine.
“If we can understand how marijuana works to end seizures, we may be able to develop novel drugs that might do a better job of treating epileptic seizures.”
Epilepsy is one of the most common neurological conditions, characterized by spontaneously recurrent seizures. Approximately 1 percent of Americans have epilepsy, and 30 percent of those patients are resistant to conventional anticonvulsant drug treatments.
Cannabinoids have been used as a natural remedy for seizures for thousands of years, and studies since at least 1974 have found that the primary psychoactive compound in marijuana displays anticonvulsant properties.”
“Six-year-old Jayden David violently shakes on the ground, his blue eyes vacant and then filled with searing pain. The video shows an unvarnished look at a seizure, something Jayden once experienced routinely.
Not anymore, says his father, thanks to medical marijuana.
Before he started taking a liquid, nonpsychoactive form of marijuana, Jayden couldn’t walk, eat solid food or take a bath.
He has Dravet’s syndrome, a rare and catastrophic form of childhood epilepsy. It has triggered seizures so frequent that 44 times he has been rushed to the hospital in an ambulance, his distraught father by his side.
Jayden’s doctors prescribed 22 anti-seizure pills a day, which controlled the seizures but left him immobilized due to the side effects.
“He’s in pain and suffering and crying,” said Jayden’s father, Jason David. “You can’t help him no matter what. What are you supposed to do? You have to do whatever it takes to save their life.”
Last year, he had enough. Delirious with fatigue and emotional pain, Jason David called his motherto say he wanted to put a gun to his head, just to end the heartbreak of seeing his son suffer. His mother convinced him to not give up.
David turned to something he had seen on television: medical marijuana.
On June 4, 2011, David gave his son marijuana. For the first time since Jayden was 4 months old, the boy went through an entire day without a seizure.
“Instead of medical marijuana, this is miracle marijuana,” said David, holding up a jam jar full of liquefied and cooled cannabis.”
“Medical marijuana shouldn’t be for ‘adults only’.
My 9-year-old daughter has Aicardi syndrome, a rare genetic disorder that causes extremely hard-to-control seizures, debilitation, disability and early mortality. She began having seizures at three months of age, and since that time has had multiple seizures every day, with rare exception — probably to the tune of nearly 200,000 seizures in her lifetime…
She is one of the 3 million Americans who have epilepsy, and one of the 40 percent whose seizures cannot be controlled by anti-seizure drugs. She has tried 10 anti-seizure medications as well as a high-protein/low-carbohydrate diet called the ketogenic diet; she takes three anti-seizure medications at once and has a vagus nerve stimulator implant that sends mild electrical pulses to the brain. These drugs help her, but she nonetheless experiences an average of three seizures every day. Moreover, the medications cause persistent side effects that negatively impact her quality of life, particularly her gastrointestinal, bone, dental, cognitive and mental health.
The Illinois Senate Executive Committee recently voted, 10-5, to move the House-passed medical marijuana legislation to the Senate for a vote. The bill is expected to pass, and though Gov. Pat Quinn has not committed to signing it, the general expectation is that the bill will become law. This should be received as great news for the many people with “debilitating” conditions that the bill is supposed to help — people for whom medical science has documented real, measurable and safe outcomes of the controlled use of cannabis or its component of chemical compounds.
It’s too bad that the legislature has ignored the medical needs of some of the most debilitated, and most vulnerable, patients in the state: children with epilepsy.
Imagine her father’s and my reaction upon learning that the legislature, in its concern not to send a “message” to kids that it is safe to smoke marijuana, decided that kids like ours, for whom medical cannabis has the potential to be as safe and effective as typical anti-seizure drugs, should be excluded from the benefits of this new law.
They have done so, I hope, only out of ignorance…
There is no likelihood that my daughter will become a drug addict from using a compound within cannabis in a medically controlled setting. There is, however, a good chance that participation in a controlled study of these compounds could open the door to new treatments for her, and the many children like her, who desperately need medical innovation to save or improve their lives.”
“Marijuana Replaces 22 Different Anti-Seizures Pills, Helps Prevent Seizures
As if the medical marijuana industry wasn’t controversial enough—with opponents arguing it encourages drug addiction and crime and supporters citing years of research to the contrary—there are now children benefiting from it. While there are several cases across the country of children being given various forms of cannabis to treat disease and illness, the case of 6-year old Jayden David is getting a particularly heavy dose of attention, where marijuana helped the boy beat severe epileptic seizures.”
“A California father’s desperate quest to find a viable solution to his young son’s rare form of epilepsy has led him to incredible success in medicinal marijuana. The Los Angeles Times (LAT) reports that Jason David’s son Jayden now functions normally, eats solid food, and takes only four prescription medications for his condition rather than the 22 he had been takingprior to starting the cannabis protocol.Young Jayden suffers from an extremely rare, and potentially fatal, epileptic condition known as Dravet syndrome that is categorized as a “catastrophic form of intractable epilepsy.” For Jayden, symptoms of the condition have included things like intense “grand mal” seizure fits, continuous muscle twitching, inability to respond to or interact with others, difficulty chewing, and frequent screaming episodes.
According to Jayden’s father Jason, Jayden had spent most of his life either sleeping or seizing, which put incredible strain on the family as it unsuccessfully tried using prescription drug after prescription drug to at least ease Jayden’s symptoms. But Jayden’s condition only got progressively worse in response to pharmaceuticals, which led Jason to actually consider committing suicide as he says he simply could no longer bear watching his son suffer in this horrific way.
After praying intensely about the situation and meeting with their local religious congregation for guidance; however, the Davids stumbled upon medical marijuana, and particularly cannabidiol (CBD), one of the many cannabinoid compounds naturally found in certain varieties of marijuana. Following a period of heavy research into the history and effectiveness of CBD, Jason decided it was worth giving the treatment a try with his son — and upon doing so, the Davids observed an almost immediate improvement in Jayden’s condition.”
“Six-year-old Charlotte Figi, a picture of precious in her “Gatsby”-style bob and blue toenails, stands patiently as her mother reaches up her dress to change her out of her soiled Pull-Ups. – Charlotte never says a word. She hasn’t in the past hour, and won’t for at least another 30 minutes, when she finally whispers the name of a visitor who is about to leave.
In the Figi household, these are signs of progress: Charlotte saying something. Charlotte eating and drinking. Charlotte standing and walking.
Charlotte breathing.
About 18 months ago, in the winter of 2011, Paige and Matt Figi signed a “do not resuscitate” order telling medical personnel to forgo life-saving measures for their daughter and let fate take its course.
They’d done all they could to control the seemingly endless, violent seizures that hit Charlotte 20, 40, 60 times a day. They put her on an extreme diet. They tried at least a dozen medications, many with harmful side effects. Despite some promising starts, nothing worked. And the rescue medications they were giving her to stop the seizures in fact stopped her breathing. CPR brought her back to life more than once.
After years of watching a cruel, incurable genetic disorder called Dravet Syndome rob their daughter of her basic bodily functions and send her into convulsions that caused head injuries and broken teeth, they had reached the end.
“We really thought, this is a horrible existence; she’s not going to live much longer.” Paige says. “This is not a life for her. This is torture. She is suffering all day. I’m not OK with this. She wasn’t even human anymore. She’d lie in my arms drooling, seizing, screaming and crying.”
Then, in an act of desperation, or inspiration – or maybe both – Matt called Paige from overseas, where he was working, and suggested a radical approach to Charlotte’s treatment.
“We need to try cannabis for Charlotte,” he told Paige. “We live in a compassionate state.”
Fifteen months later, the little girl with the DNR order is standing in the kitchen of their Black Forest home with her mother getting her Pull-Ups changed, cuddling in the arms of a visitor, playing with toys and strategically pushing the buttons on her “talker,” an electronic device that communicates when Charlotte can’t.
Her seizures have dropped from 1,200 a month to three, and the ones she has are shorter in duration and less severe. She’s off all the other medications with their troubling side effects. And, as one of the youngest medical marijuana patients in Colorado, her dramatic turnaround is starting to draw national attention, with a CNN report on the horizon.”
