Category Archives: Leukemia

Want Leukemia “awareness”? Please, BE AWARE:

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“Increase in rare childhood cancers linked to air pollution exposure” http://in.news.yahoo.com/increase-rare-childhood-cancers-linked-air-pollution-exposure-063414538.html
“Air Pollution and Childhood Cancer. A new study finds a link between air pollution exposure during pregnancy and childhood leukemia.”
http://health.yahoo.net/videos/healthday/air-pollution-and-childhood-cancer
“UCLA researchers find potential link between auto pollution, some childhood cancers” http://newsroom.ucla.edu/portal/ucla/ucla-researchers-link-auto-pollution-244911.aspx
“UCLA Researchers Find Potential Link Between Air Pollution And Childhood Cancer” http://losangeles.cbslocal.com/2013/04/09/ucla-researchers-find-potential-link-between-air-pollution-and-childhood-cancer/
“Leukemia, Other Pediatric Cancers Linked to Air Pollution”
http://www.empr.com/leukemia-other-pediatric-cancers-linked-to-air-pollution/article/288041/

“Air Pollution From Traffic Linked With Childhood Cancer” http://www.huffingtonpost.com/2013/04/09/air-pollution-traffic-childhood-cancer_n_3039048.html

“Leukemia, Other Pediatric Cancers Linked to Air Pollution” http://www.empr.com/leukemia-other-pediatric-cancers-linked-to-air-pollution/article/288041/

“NIH study finds childhood CT scans linked to leukemia and brain cancer later in life” http://nih.gov/news/health/jun2012/nci-07.htm
“NIH study finds childhood CT scans linked to leukemia and brain cancer later in life” http://www.cancer.gov/newscenter/newsfromnci/2012/CTpediatricLancet
“Childhood CT Scans Linked to Leukemia and Brain Cancer Later in Life” http://news.cancerconnect.com/childhood-ct-scans-linked-to-leukemia-and-brain-cancer-later-in-life/
“Childhood CT Scans Linked to Later Leukemia, Brain Cancer” http://www.medscape.com/viewarticle/765223

“Multiple CT scans in kids linked to later cancer risk” http://www.nbcnews.com/health/multiple-ct-scans-kids-linked-later-cancer-risk-6C10272110

“Link Between X-Rays And Increased Childhood Leukemia Risk”
http://www.medicalnewstoday.com/articles/203521.php
“X-rays can cause childhood leukemia”
http://www.naturalnews.com/029961_X-rays_leukemia.html

“X-Rays Linked to Increased Childhood Leukemia Risk” http://www.sciencedaily.com/releases/2010/10/101004101324.htm

“Survival at a Cost: Common Cancer Treatment Carries Huge Risks” http://abcnews.go.com/Health/radiation-therapy-linked-development-secondary-cancers-heart-disease/story?id=15864706

“Treatments linked to the development of second cancers”
http://www.cancer.org/cancer/cancercauses/othercarcinogens/medicaltreatments/secondcancerscausedbycancertreatment/second-cancers-caused-by-cancer-treatment-treatments-linked-to-second-cancers

“Decades Later, Chernobyl Accident Yields Clues to Leukemia Risk”
http://www.cancer.gov/ncicancerbulletin/111312/page5
“Exposure to low-level radiation can cause leukemia, U.S.-Ukraine study of Chernobyl cleanup workers finds” http://www.japantimes.co.jp/news/2012/11/09/national/exposure-to-low-level-radiation-can-cause-leukemia-u-s-ukraine-study-of-chernobyl-cleanup-workers-finds/
“Risk for Acute Myeloid Leukemia Linked to Chemotherapy”
http://www.medscape.com/viewarticle/779653
“Cancer Chemotherapy Tied to Slight Rise in Risk for Leukemia” http://www.drugs.com/news/cancer-chemotherapy-tied-slight-rise-risk-leukemia-43125.html
“Chemo Raises Leukemia Risk Slightly in Older Women”
http://www.breastcancer.org/research-news/20070924b
“Woops! Study Accidentally Finds Chemotherapy Makes Cancer Far Worse” http://naturalsociety.com/chemotherapy-makes-cancer-far-worse/
“Shock study: Chemotherapy can backfire, make cancer worse by triggering tumor growth” http://www.nydailynews.com/life-style/health/shock-study-chemotherapy-backfire-cancer-worse-triggering-tumor-growth-article-1.1129897
“Immunity Boosters Linked to Leukemia”
http://www.cbsnews.com/2100-500368_162-2441362.html
“Drugs That Boost Immunity During Cancer Chemo May Carry Leukemia Risk” http://www.webmd.com/breast-cancer/news/20070206/immunity-boosters-linked-leukemia
“Study: GMOs linked to leukemia and anemia”
http://www.digitaljournal.com/article/350126
“Agent Orange Linked to Childhood Cancer”
http://abcnews.go.com/Health/story?id=117503&page=1
“Agent Orange, Leukemia Linked”
http://www.cbsnews.com/2100-204_162-537775.html
“Insecticides: Potential Leukemia Risk. Study Examines Possible Link Between Head Lice Shampoo and Childhood Leukemia”
http://www.webmd.com/cancer/news/20060118/insecticides-potential-leukemia-risk
“Bug Spray Use Linked to Childhood Leukemia” http://www.medpagetoday.com/HematologyOncology/Leukemia/2503
“Fertility drugs linked to leukaemia”
http://news.uk.msn.com/uk/fertility-drugs-linked-to-leukaemia
“High blood sugar ups mortality in leukemia patients”
http://www.reuters.com/article/2007/08/30/us-high-blood-sugar-idUSKUA07460320070830
“NutraSweet Linked to Leukemia and Lymphoma”
http://www.naturalnews.com/026656_aspartame_leukemia_formaldehyde.html
“Sucralose Causes Cancer Concern” http://www.medicalnewstoday.com/articles/244603.php
“Splenda May Not Be So Splendid After All” http://news.yahoo.com/splenda-may-not-splendid-194239789.html
“Sweetener ‘linked’ to leukaemias” http://news.bbc.co.uk/2/hi/health/4683371.stm
“Diet Soft Drinks, Sodas can cause leukemia and lymphoma” http://www.agoracosmopolitan.com/news/headline_news/2012/11/02/4720.html
“Aspartame is linked to leukemia and lymphoma in new landmark study on humans” http://www.naturalnews.com/037772_aspartame_leukemia_lymphoma.html
“Doctors find link between obesity, leukemia” http://abclocal.go.com/kabc/story?id=7670509
“Obesity and Leukemia: Fat May Offer Sanctuary to Cancer Cells”
http://www.usnews.com/science/articles/2009/09/23/linking-obesity-with-leukemia-relapses
“Tea Ingredient Fights Leukemia. Lab Study: Green, Black, and Oolong Tea Boosts Immune Responses”
http://www.webmd.com/cancer/news/20050404/tea-ingredient-fights-leukemia

“Higher lymphoma risk for those living close to benzene-releasing sites, Georgia study finds” http://medcitynews.com/2013/07/higher-lymphoma-risk-for-those-living-close-to-benzene-releasing-sites-georgia-study-finds/

“Home distance from benzene sites linked to lymphoma risk”
http://www.nlm.nih.gov/medlineplus/news/fullstory_139158.html

“Benzene Exposure Linked to Increased Rate of NHL”
http://www.medscape.com/viewarticle/808573
“Samsung Chip Factory Causes Cancer, South Korea Government Finds” http://www.huffingtonpost.com/2012/12/14/samsung-chip-factory-cancer_n_2298294.html
“China’s Cancer-Causing Factories”
http://www.cbsnews.com/8301-18563_162-5237961.html
“Formaldehyde and Leukemia: Epidemiology, Potential Mechanisms and Implications for Risk Assessment” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2839060/
“Formaldehyde Exposure among Industrial Workers Is Associated with Increased Risk of Cancers of the Blood and Lymphatic System” http://www.cancer.gov/newscenter/newsfromnci/2009/formaldehyde
“Hexavalent Chromium, Cancer-Causing Toxin, Common in Tap Water: What to Do” http://www.cbsnews.com/8301-504763_162-20026157-10391704.html
“Chromium in Drinking Water Causes Cancer”
http://www.scientificamerican.com/article.cfm?id=chromium-water-cancer
“Lack of vitamin D in patients with leukemia “ups death risk””
http://www.dailyindia.com/show/406851.php
“The Vitamin D and Cancer Connection: Research Shows the Link”
http://news.cancerconnect.com/the-vitamin-d-and-cancer-connection-research-shows-the-link/

“Insufficient Vitamin D Levels in Chronic Lymphocytic Leukemia Patients Linked to Cancer Progression and Death”
http://www.sciencedaily.com/releases/2010/11/101104094038.htm

“Mayo Clinic Finds Insufficient Vitamin D Levels in CLL Patients Linked to Cancer Progression and Death”
http://www.mayoclinic.org/news2010-rst/6033.html

Be aware:  http://www.thctotalhealthcare.com/category/leukemia/

 ferrando stock child

The CB2 cannabinoid receptor signals apoptosis via ceramide-dependent activation of the mitochondrial intrinsic pathway.

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“Delta9-tetrahydrocannabinol and other cannabinoids exert pro-apoptotic actions in tumor cells via the CB2 cannabinoid receptor…

 Here we used the human leukemia cell line Jurkat-that expresses CB2 as the unique CB receptor-to investigate…

 In summary, results presented here show that CB2 receptor activation signals apoptosis via a ceramide-dependent stimulation of the mitochondrial intrinsic pathway.”

http://www.ncbi.nlm.nih.gov/pubmed/16624285

Cannabinoid receptors expression in bone marrow trephine biopsy of chronic lymphocytic leukaemia patients treated with purine analogues.

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“Cannabinoid receptors CB1 and CB2 are part the endocannabinoid system that plays an important role in the process of proliferation and apoptosis of different neoplastic cells. B-cell chronic lymphocytic leukaemia is one of the diseases in which these processes are altered… The aim of our study was the assessment of cannabinoid receptor expression on the B-lymphocytes in bone marrow trephine biopsy from leukaemic patients at diagnosis and after purine analogue treatment….

CONCLUSION:

The study provides original evidence for the existence of cannabinoid receptors on B-lymphocytes in chronic lymphocytic leukaemia patients. The receptors are thought to be a new structure that can modify the course of the disease and may be considered as a new target in leukaemia treatment.”

http://www.ncbi.nlm.nih.gov/pubmed/18004250

Δ9-Tetrahydrocannabinol-Induced Apoptosis in Jurkat Leukemia T Cells Is Regulated by Translocation of Bad to Mitochondria

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“Cannabinoids, the biologically active constituents of marijuana (Cannabis sativa)…

Plant-derived cannabinoids, including Δ9-tetrahydrocannabinol (THC), induce apoptosis in leukemic cells…

cannabinoids were shown to inhibit the proliferation of several human cancer cell lines, including leukemia…

Together, these data suggested that Raf-1/MEK/ERK/RSK-mediated Bad translocation played a critical role in THC-induced apoptosis in Jurkat cells…

THC and other cannabinoids can induce apoptosis in a variety of tumor cell lines, thereby raising the possibility of the use of cannabinoids as novel anticancer agents…”

Full text: http://mcr.aacrjournals.org/content/4/8/549.long

Enhancing the in vitro cytotoxic activity of Delta9-tetrahydrocannabinol in leukemic cells through a combinatorial approach.

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“Delta(9)-Tetrahydrocannabinol (THC) is the active metabolite of cannabis, which has demonstrable cytotoxic activity in vitro. In support of our previously published data, we have investigated the interactions between THC and anti-leukemia therapies and studied the role of the signalling pathways in mediating these effects.

 Results showed clear synergistic interactions between THC and the cytotoxic agents in leukemic cells…

 Overall, these results demonstrate for the first time that a combination approach with THC and established cytotoxic agents may enhance cell death in vitro. Additionally the MAPK/ERK pathway appears responsible in part for these effects.”

http://www.ncbi.nlm.nih.gov/pubmed/18608861

Cannabidiol-Induced Apoptosis in Human Leukemia Cells: A Novel Role of Cannabidiol in the Regulation of p22phox and Nox4 Expression

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“Marijuana has been suggested as a potent therapeutic agent alleviating such complications as intraocular pressure in glaucoma and cachexia, nausea, and pain in AIDS and cancer patients. A number of recent studies now suggest the possible use of these compounds for the treatment of cannabinoid receptor-expressing tumors…

In the current study, we examined the effects of the nonpsychoactive cannabinoid, cannabidiol, on the induction of apoptosis in leukemia cells. Exposure of leukemia cells to cannabidiol led to cannabinoid receptor 2 (CB2)-mediated reduction in cell viability and induction in apoptosis. Furthermore, cannabidiol treatment led to a significant decrease in tumor burden and an increase in apoptotic tumors in vivo…

Together, the results from this study reveal that cannabidiol, acting through CB2 and regulation of Nox4 and p22phox expression, may be a novel and highly selective treatment for leukemia…

In summary, the current study demonstrates that CBD-induced apoptosis may constitute a novel approach to treat malignancies of the immune system…”

Full text: http://molpharm.aspetjournals.org/content/70/3/897.long

Cannabidiol, unlike synthetic cannabinoids, triggers activation of RBL-2H3 mast cells

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“Plant-derived cannabinoids, such as Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD), the main psychoactive and nonpsychoactive components of cannabis, respectively, possess myriad pharmacological properties…

Cannabidiol (CBD), a prominent psychoinactive component of cannabis with negligible affinity for known cannabinoid receptors, exerts numerous pharmacological actions, including anti-inflammatory and immunosuppressive effects…

Together, these results support existence of yet-to-be identified sites of interaction, i.e., receptors and/or ion channels associated with Ca2+ influx of natural cannabinoids such as CBD and THC, the identification of which has the potential to provide for novel strategies and agents of therapeutic interest.”

Full text: http://www.jleukbio.org/content/81/6/1512.long

Gamma-irradiation enhances apoptosis induced by cannabidiol, a non-psychotropic cannabinoid, in cultured HL-60 myeloblastic leukemia cells.

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“Two non-psychotropic cannabinoids, cannabidiol (CBD) and cannabidiol-dimethylheptyl (CBD-DMH), induced apoptosis in a human acute myeloid leukemia (AML) HL-60 cell line…

  Caspase-3 activation was observed after the cannabinoid treatment, and may represent a mechanism for the apoptosis.

Our data suggest a possible new approach to treatment of AML.”

http://www.ncbi.nlm.nih.gov/pubmed/14692532

Tetrahydrocannabinol inhibits adenyl cyclase in human leukemia cells.

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“Delta 9-tetrahydrocannabinol has been shown to induce incomplete maturation in ML2 human leukemia cell lines.

We extend the observation of its induction of morphologic maturation to HL60 cells and of its induction of growth restriction to HL60 and K562 cells.

 We show that tetrahydrocannabinol reduces the cyclic AMP content of ML2 cells.

 Finally we demonstrate that this agent inhibits adenyl cyclase activity in ML2 cell membrane-enriched fractions.

This finding in myeloid cells is compatible with one hypothesis of cannabinoid action in neuronal cells.”

http://www.ncbi.nlm.nih.gov/pubmed/2154651

Cannabinoids induce incomplete maturation of cultured human leukemia cells.

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“Monocyte maturation markers were induced in cultured human myeloblastic ML-2 leukemia cells after treatment for 1-6 days with 0.03-30 microM delta 9-tetrahydrocannabinol (THC), the major psychoactive component of marijuana…

 Cannabinoids induce incomplete maturation of cultured human leukemia cells…

Findings obtained from this system may have important implications for studies of cannabinoid effects on normal human bone-marrow progenitor cells.”

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC298868/