Category Archives: Skin Cancer

Medical Marijuana Inc Announces Positive Developments in Recent Studies Using Cannabidiol (CBD) Compound; NBC News, ABC News and Huffington Post Report California Pacific Medical Center’s Findings That CBD Stops Metastasis in Aggressive Cancers – The Wall Street Journal

Posted on by
Reply

“Medical Marijuana Inc Announces Positive Developments in Recent Studies Using Cannabidiol (CBD) Compound; NBC News, ABC News and Huffington Post Report California Pacific Medical Center’s Findings That CBD Stops Metastasis in Aggressive Cancers

SAN DIEGO, May 28, 2013 (GLOBE NEWSWIRE) — Medical Marijuana Inc (OTC Pink:MJNA) is pleased to inform shareholders and the general public of recent developments in the research involving Cannabidiol (CBD) and other Phyto-cannabinoids.

The Following is taken from a Huffington Post interview with Dr. McAllister and Dr. Desprez:

A pair of scientists at California Pacific Medical Center in San Francisco has found that a compound derived from marijuana could stop metastasis in many kinds of aggressive cancer, potentially altering the fatality of the disease forever.

“It took us about 20 years of research to figure this out, but we are very excited,” said Pierre Desprez, one of the scientists behind the discovery, to The Huffington Post. “We want to get started with trials as soon as possible.”

The Daily Beast first reported on the finding, which has already undergone both laboratory and animal testing, and is awaiting permission for clinical trials in humans.

Desprez, a molecular biologist, spent decades studying ID-1, the gene that causes cancer to spread. Meanwhile, fellow researcher Sean McAllister was studying the effects of Cannabidiol, or CBD, a non-toxic, non-psychoactive chemical compound found in the cannabis plant. Finally, the pair collaborated, combining CBD and cells containing high levels of ID-1 in a petri dish.

“What we found was that his Cannabidiol could essentially ‘turn off’ the ID-1,” Desprez told HuffPost. The cells stopped spreading and returned to normal.

“We likely would not have found this on our own,” he added. “That’s why collaboration is so essential to scientific discovery.”

Desprez and McAllister first published a paper about the finding in 2007. Since then, their team has found that CBD works both in the lab and in animals. And now, they’ve found even more good news.

“We started by researching breast cancer,” said Desprez. “But now we’ve found that Cannabidiol works with many kinds of aggressive cancers–brain, prostate–any kind in which these high levels of ID-1 are present.”

Desprez hopes that clinical trials will begin immediately.

“We’ve found no toxicity in the animals we’ve tested, and Cannabidiol is already used in humans for a variety of other ailments,” he said. Indeed, the compound is used to relieve anxiety and nausea, and, since it is non-psychoactive, does not cause the “high” associated with THC.

While marijuana advocates will surely praise the discovery, Desprez explained that it’s not so easy as just lighting up.

“We used injections in the animal testing and are also testing pills,” he said. “But you could never get enough Cannabidiol for it to be effective just from smoking.”

Additional Information:

Dr. McAllister & CBD Research

Dr. Sean McAllister says that he is ready to begin testing CBD on humans to evaluate anti-cancer properties. Dr. McAllister and colleague Pierre Desprez, PhD from California Pacific Medical Center have previously mentioned, “Cannabidiol offers hope of a non-toxic therapy that could treat aggressive forms of cancer without any of the painful side effects of chemotherapy.” “We found that this one compound, CBD, had a specific effect on metastatic cancer cells, very aggressive tumor cells. CBD in animal studies has been used to ‘switch off’ a specific gene regulator.” Dr. McAllister explains: “We find when you treat with CBD, you down regulate the expression of this protein and that inhibits the disease process.” Dr. McAllister and Dr. Desprez have developed a synthetic version of CBD, which they say targets a specific gene in the body related to the spread of cancer (metastasis). Article: http://abclocal.go.com/kgo/story?section=news/health&id=9057615

Additional Cannabidiol Information

ABC News-

http://abclocal.go.com/kgo/story?section=news/health&id=9057615

Huffington Post-

http://www.huffingtonpost.com/2012/09/19/marijuana-and-cancer_n_1898208. html?ncid=edlinkusaolp00000003&ir=Weird%20News

US. National Cancer Institute

http://www.cancer.gov/cancertopics/pdq/cam/cannabis/healthprofessional/p age4

Additional Dr. McAllister Publications

http://www.ncbi.nlm.nih.gov/pubmed/?term=Sean%20McAllister

Additional Published Material on Cannabidiol (CBD)

http://www.ncbi.nlm.nih.gov/gquery/?term=CANNABIDIOL”

More: http://online.wsj.com/article/PR-CO-20130528-906109.html

Marijuana mouth spray for cancer patients tough to abuse – NBC

Posted on by
Reply

Image result for nbc news vitals

“The medical marijuana drug Sativex, which could be approved in the United States in the coming years as a treatment for pain relief, has little potential for abuse, experts say.

The British pharmaceutical company GW Pharmaceuticals is currently testing the drug, which is delivered as a mouth spray and called Sativex, in clinical trials. The company plans to seek U.S. Food and Drug Administration approval for the drug as a treatment for cancer pain when the trials are completed, likely sometime in 2014, a spokesperson for GW Pharmaceuticals told MyHealthNewsDaily.

The active ingredients in Sativex, known as cannabinoids, are derived from the cannabis plant. It is the first marijuana-based drug to be made by extracting the compounds from the plant, rather than synthesizing them. Two other drugs, Marinol and Cesamet, based on synthetic cannabinoids, were approved by the FDA in the 1980s.”

More: http://vitals.nbcnews.com/_news/2012/01/31/10280678-marijuana-mouth-spray-for-cancer-patients-tough-to-abuse?lite

Cannabis Science Reports Cancer Tumors Continues to Shrink and Die as Apparent Pieces of the Dying Cancer Tumors Begin to Fall off as Evidenced in Newest Photos of the 3rd Squamous Cell Carcinoma Patient

Posted on by
Reply

“Cannabis Science, Inc. a pioneering U.S. biotech company developing pharmaceutical cannabis (marijuana) products, is pleased to release new updated photos from the 3rd cancer patient self-administering cannabis extracts. This patient has severe squamous cell carcinoma on their head that was resistant to chemo and radiation therapy, which left the patient with large tumor masses on their head. With these new photo updates you can see the drastic change in appearance of the tumors and how the topical cannabis extract is killing them. 

Cannabis Science has been working very closely with this patient and is continuing to see vast improvement to his treatment resistant squamous cell carcinoma. Prior to using cannabis-based extracts this patient had received radiation and chemotherapy for his condition. This patient notices a huge difference between the treatments and had stated, “While on radiation treatments, each day was stressful and after each treatment I felt horrible as if my entire body was dying organ by organ. While using the Oil, I have noticed that my overall health seems much better. I sleep the recommended hours, unlike the insomnia I suffered while on radiation, and unlike the radiation that caused the restless sleep and nightmares, on the Oil I sleep like a baby.” The patient also mentioned that while showering they would see bits and pieces of the tumor falling off with the water as he was cleaning his head.

This patient is very pleased with the results of the topical cannabis extract so far and said he enjoyed absolutely nothing about radiation and felt constantly sick and just overall unhealthy, but with using the oil he said, “I feel myself being restored, not tortured.””

More: http://www.drugs.com/clinical_trials/cannabis-science-reports-cancer-tumors-continues-shrink-die-apparent-pieces-dying-cancer-tumors-13168.html

Cannabis says success in 4th brand new self-administering cancer patient

Posted on by
Reply

“Cannabis Science Inc., a pioneering US biotech company developing pharmaceutical cannabis (marijuana) products, has introduced 4th cancer patient with basal cell carcinoma (skin cancer) on his left nostril, who is self-administering a topical cannabis extract and having noticeable results.

Cannabis Science has received images and documented information from this 4th patient who has basal cell carcinoma on his left nostril. The patient is enrolled in a photographic mole-mapping programme at the University of Colorado Hospital and is examined annually. The last time he was examined was in October of 2011, where his doctors found a small bump on his left nostril that was less and 1/8″ in diameter, and believed it to be basal cell carcinoma. At that time it was too early to be certain if it was in-fact basal cell carcinoma.

By January 2012 the small bump on his left nostril had grown slightly and had developed a rough scaly texture similar to his previous episodes of basal cell carcinoma. The patient began self-administering cannabis extract oil (CT-1) topically to the spot on his left nostril in the middle of January. The patient immediately reported minor irritation of the spot but that the surrounding healthy skin was not irritated. The rough scaly texture and the minor irritation disappeared by day four of treatment and by day nine of treatment the bump had shrunk considerably and was almost imperceptible to the touch. In these three images you can notice a significant reduction in the lesion.

This patient has a history of having five different episodes of basal cell carcinoma starting at the age of 27, and had one malignant melanoma at age 35. He is now 46, and has suffered from numerous severe sunburns which caused blistering and peeling. This patient was diagnosed with dysplastic nevus syndrome (over 100 atypical moles) and has been told that he is certain to have additional melanomas at some point in the future. Doctors have already confirmed that he has had basal cell carcinoma on his right jaw line, which resulted to Mohs procedure that was performed in December of 2011.

Cannabis Science, Inc. is at the forefront of pharmaceutical grade medical marijuana research and development. The second formulations will address the needs of patients choosing to use concentrated cannabis extracts to treat their ailments.

 Eventually, all Americans will have access to a safe and effective FDA approved medicine regardless of which state they live in.”

http://pharmabiz.com/NewsDetails.aspx?aid=67354&sid=2 

Physician’s documentation confirms successful treatment of basal cell carcinoma with topical cannabis extract

Posted on by
Reply

“We are pleased to announce that we have physician’s documentation that confirms the successful treatment of basal cell carcinoma that resulted from the application of a topical cannabis extract.” 

Currently, there is a tremendous amount of controversy with respect to the effects that cannabinoids have on cancers. Endocannabinoids, phytocannabinoids, and synthetic cannabinoids have demonstrated cancer killing and anti-metastatic properties in tissue culture and in animal models.

While formal, proper, FDA approved clinical trials that would prove or disprove the therapeutic potential of cannabis extracts for treating cancers; trials have not been carried out. Nevertheless, a significant number of anecdotal observations have accumulated that suggest people suffering from a variety of cancers appear to have been cured by ingesting what is known as “Rick Simpson’s hemp oil”.”

More: http://www.news-medical.net/news/20110407/Physicians-documentation-confirms-successful-treatment-of-basal-cell-carcinoma-with-topical-cannabis-extract.aspx

Cannabis Science extracts benefit squamous cell carcinoma cancer and skin cancer patients

Posted on by
Reply

“We stumbled upon this news a couple weeks back regarding Cannabis Science, Inc. (OTCBB:CBIS.OB) reported the continuing successful progress by two patients who have been topically self-administering Cannabis Science extracts for Squamous Cell Carcinoma Cancer and Skin Cancer.

According to their earlier press releases, these patients have photo-documented dramatic results that the Company will release to the public once treatment is completed and has been properly vetted by clinical biopsy. The Company, in conjunction with several Colorado-licensed dispensaries and physicians, consults with a number of cancer patients who are seeking to inform themselves of the current peer-reviewed scientific literature, regarding modern and historical use of cannabis preparations for treating cancers so that they can make informed decisions regarding their self-directed cancer treatment.

Cannabis has an outstanding safety profile as determined in 1988 by Federal Administrative Law Judge Francis Young who recommended cannabis be removed from Schedule I. The refusal of the DEA to follow this recommendation has resulted in 16 states allowing some form of medical marijuana access for their citizens. Numerous other states are moving in this direction. Consequently, patients in states with medical marijuana laws are able to make an informed decisions to try various state-legal cannabis preparations and to determine what is most effective for their particular condition. As a result, there is an unprecedented accumulation of “anecdotal” data.

Cannabis Science went on to mention that it’s making cannabis-based medicines available to the public as rapidly as possible.”

More: http://www.news-medical.net/news/20120107/Cannabis-Science-extracts-benefit-squamous-cell-carcinoma-cancer-and-skin-cancer-patients.aspx

Bay Area Researchers Claim Cannabis Can Cure Cancer

Posted on by
Reply

“Marijuana has been used for medicinal purposes–relieving stress and pain and fighting hunger and nausea–for centuries if not millennia. But now, a pair of doctors in San Francisco claim that they’ve compiled reliable data showing that a certain compound in cannabis–cannabidiol–may actually cure cancer.”

Bay Area Researchers Claim Cannabis Can Cure Cancer

“Unlike THC, the ingredient in marijuana that makes you feel stoned, cannabidiol is a non-toxic compound of the plant that has no psychoactive qualities, and it’s been the focus of an ongoing series of trials at the San Francisco-based California Pacific Medical Center. There, physicians Sean McAllister and Pierre Desprez claim they’ve successfully used cannabidiol to fight animal genes involved in the spread of cancer. Now they hope to be allowed to conduct anti-cancer research using cannabidiol on actual humans.”

Cannabinoid receptor systems: therapeutic targets for tumour intervention.

Posted on by
Reply

Image result for taylor & francis online

“The past decade has witnessed a rapid expansion of our understanding of the biological roles of cannabinoids and their cognate receptors. It is now certain that Delta9-tetrahydrocannabinol, the principle psychoactive component of the Cannabis sativa plant, binds and activates membrane receptors of the 7-transmembrane domain, G-protein-coupled superfamily.

Several putative endocannabinoids have since been identified, including anandamide, 2-arachidonyl glycerol and noladin ether. Synthesis of numerous cannabinomimetics has also greatly expanded the repertoire of cannabinoid receptor ligands with the pharmacodynamic properties of agonists, antagonists and inverse agonists.

Collectively, these ligands have proven to be powerful tools both for the molecular characterisation of cannabinoid receptors and the delineation of their intrinsic signalling pathways. Much of our understanding of the signalling mechanisms activated by cannabinoids is derived from studies of receptors expressed by tumour cells; hence, this review provides a succinct summary of the molecular pharmacology of cannabinoid receptors and their roles in tumour cell biology.

Moreover, there is now a genuine expectation that the manipulation of cannabinoid receptor systems may have therapeutic potential for a diverse range of human diseases. Thus, this review also summarises the demonstrated antitumour actions of cannabinoids and indicates possible avenues for the future development of cannabinoids as antitumour agents.” http://www.ncbi.nlm.nih.gov/pubmed/14640910

http://www.tandfonline.com/doi/abs/10.1517/14728222.7.6.749

The endocannabinoid system and its therapeutic exploitation.

Posted on by
Reply

Image result for Nat Rev Drug Discov.

“The term ‘endocannabinoid’ – originally coined in the mid-1990s after the discovery of membrane receptors for the psychoactive principle in Cannabis, Delta9-tetrahydrocannabinol and their endogenous ligands – now indicates a whole signalling system that comprises cannabinoid receptors, endogenous ligands and enzymes for ligand biosynthesis and inactivation. This system seems to be involved in an ever-increasing number of pathological conditions. With novel products already being aimed at the pharmaceutical market little more than a decade since the discovery of cannabinoid receptors, the endocannabinoid system seems to hold even more promise for the future development of therapeutic drugs. We explore the conditions under which the potential of targeting the endocannabinoid system might be realized in the years to come.”  http://www.ncbi.nlm.nih.gov/pubmed/15340387

http://www.nature.com/nrd/journal/v3/n9/full/nrd1495.html

Active Component Of Marijuana Has Anti-Cancer Effects, Study Suggests

Posted on by
Reply

“Guillermo Velasco and colleagues, at Complutense University, Spain, have provided evidence that suggests that cannabinoids such as the main active component of marijuana (THC) have anticancer effects on human brain cancer cells.

In the study, THC was found to induce the death of various human brain cancer cell lines and primary cultured human brain cancer cells by a process known as autophagy.

Consistent with the in vitro data, administration of THC to mice with human tumors decreased tumor growth and induced the tumor cells to undergo autophagy. As analysis of tumors from two patients with recurrent glioblastoma multiforme (a highly aggressive brain tumor) receiving intracranial THC administration showed signs of autophagy, the authors suggest that cannabinoid administration may provide a new approach to targeting human cancers.”  http://www.sciencedaily.com/releases/2009/04/090401181217.htm

“Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells” https://www.jci.org/articles/view/37948