“Gramicidin is a monomeric protein that is thought to non-selectively conduct cationic currents and water. Linear gramicidin is considered an antibiotic. This function is considered to be mediated by the formation of pores within the lipid membrane, thereby killing bacterial cells.

The main non-psychoactive active constituent of the cannabis plant, cannabidiol (CBD), has recently gained interest, and is proposed to possess various potential therapeutic properties, including being an antibiotic. We previously determined that CBD’s activity on ion channels could be, in part, mediated by altering membrane biophysical properties, including elasticity.

In this study, our goal was to determine the empirical effects of CBD on gramicidin currents in human embryonic kidney (HEK) cells, seeking to infer potential direct compound-protein interactions. Our results indicate that gramicidin, when applied to the extracellular HEK cell membrane, followed by CBD perfusion, increases the gramicidin current.”

https://pubmed.ncbi.nlm.nih.gov/35913948/

“One compound with amphiphilic properties is cannabidiol (CBD), the primary non-psychotropic constituent of Cannabis sativa. CBD is a clinically and experimentally substantiated therapeutic compound with efficacy against a variety of conditions, including seizure disorders (for which CBD is FDA-approved), pain, and muscle spasms. Furthermore, CBD has been suggested to have antibiotic properties.”

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0271801

“Industrial hemp, with low levels of the intoxicating cannabinoid tetrahydrocannabinol (THC), is grown for fibre and seeds. The industrial hemp industry is poised for expansion. The legalisation of industrial hemp as an agricultural commodity and the inclusion of hemp seed in foods is helping to drive the expansion of the hemp food ingredients industry.

This paper discusses the opportunity to build an industrial hemp industry, with a focus on the prospects of hemp seed and its components in food applications. The market opportunities for industrial hemp products are examined. Various aspects of the science that underpins the development of an industrial hemp industry through the food supply chain are presented. This includes a discussion on the agronomy, on-farm and post-harvest considerations and the various types of food ingredients that can be made from hemp seed. The characteristics of hemp seed meal, hemp seed protein and hemp seed oil are reviewed. Different processes for production of value-added ingredients from hemp seed, hemp seed oil and hemp seed protein, are examined. The applicability of hemp seed ingredients in food applications is reviewed. The design of hemp seed ingredients that are fit-for-purpose for target food applications, through the selection of varieties and processing methods for production of various hemp seed ingredients, needs to consider market-led opportunities. This will require an integrated through chain approach, combined with the development of on-farm and post-farm strategies, to ensure that the hemp seed ingredients and foods containing hemp seed are acceptable to the consumer.”

https://pubmed.ncbi.nlm.nih.gov/35906681/

“Overall, the opportunity to build a whole supply chain is particularly attractive for the farm sector wishing to diversify and plant sustainable crops with potential for economic returns.”

https://jcannabisresearch.biomedcentral.com/articles/10.1186/s42238-022-00156-7

“The constant search for new pharmacologically active compounds, especially those that do not exhibit toxic effects, intensifies the interest in plant-based ingredients and their potential use in pharmacotherapy.

One of the plants that has great therapeutic potential is Cannabis sativa L., a source of the psychoactive Δ⁹-tetrahydrocannabinol (Δ⁹-THC), namely cannabidiol (CBD), which exhibits antioxidant and anti-inflammatory properties, and cannabigerol (CBG)-a biologically active compound that is present in much smaller quantities.

CBG is generated during the non-enzymatic decarboxylation of cannabigerolic acid, a key compound in the process of biosynthesis of phytocannabinoids and consequently the precursor to various phytocannabinoids. By interacting with G-protein-coupled receptors, CBG exhibits a wide range of biological activities, inter alia, anti-inflammatory, antibacterial and antifungal activities, regulation of the redox balance, and neuromodulatory effects.

Due to the wide spectrum of biological activities, CBG seems to be a very promising compound to be used in the treatment of diseases that require multidirectional pharmacotherapy. Moreover, it is suggested that due to the relatively rapid metabolism of cannabigerol, determination of the concentration of the phytocannabinoid in blood or oral fluid can be used to determine cannabis use. Therefore, it seems obvious that new therapeutic approaches using CBG can be expected.”

https://pubmed.ncbi.nlm.nih.gov/35887277/

“Although plants and their components have been used in therapeutic activities for several thousand years, their conscious use as elements of drugs, dietary supplements, cosmetics, and other products exhibiting biomedical properties are the result of research carried out over the last 20 years. One of the plants whose ingredients are more and more often studied for use in biomedical and pharmaceutical activities is Cannabis sativa L. At the same time, it should be noted that compounds obtained from Cannabis sativa L. are usually considered more beneficial than synthetic ones, because the latter may cause unwanted side effects when used for longer periods of time.”

“At the moment, cannabigerol is one of the least-known phytocannabinoids found in Cannabis sativa L., which, however, shows promising potential in therapeutic actions. Considering that both CBG and its precursors and metabolites are lipophilic, it favors the penetration the penetration through biological membranes and indicates the possibility of biological activity in the lipid sphere mainly through interactions with the endocannabinoid system, including G-protein-coupled receptors. As a result of these interactions as well as direct actions, CBD exhibits antioxidant and anti-inflammatory properties, while both CBG and CBGA as well as its synthetic derivatives exhibit neuromodulatory effects. Moreover, CBG has been shown to reduce the survival of glioblastoma cells, similar to temozolomide used both in monotherapy and with CBG. So far, however, the data in this regard are inconclusive and, moreover, come from in vitro and animal studies that require validation on human tissues and cells used ex vivo, prior to possible clinical trials. No harmful effect of CBG on the human body has been found so far, and the proven biological activity indicates CBG and its derivatives as very promising natural compounds that should be thoroughly tested both in vitro and in vivo in order to unequivocally determine the therapeutic usefulness, especially with regard to inflammatory diseases. Therefore, it seems obvious that new therapeutic approaches using the non-psychoactive ingredients of Cannabis sativa L, including CBG, can be expected in the nearest future.”

https://www.mdpi.com/1422-0067/23/14/7929/htm