“Cannabis sativa is a plant used for recreational and therapeutic purposes; however, many of the secondary metabolites in the plant have not been thoroughly investigated. Stilbenes are a class of compounds with demonstrated anti-inflammatory and antioxidant properties and are present in cannabis. Many stilbenes present in cannabis have been investigated for their therapeutic effects. Fourteen stilbenes have been identified to be present in cannabis, all of which are structurally dihydrostilbenoids, with half possessing a prenylated moiety. The stilbenes summarized in this analysis show varying degrees of therapeutic benefits ranging from anti-inflammatory, antiviral, and anti-cancer to antioxidant effects. Many of the identified stilbenes have been researched to a limited extent for potential health benefits. In addition, predictive in silico modeling was performed on the fourteen identified cannabis-derived stilbenes. This modeling provides prospective activity, pharmacokinetic, metabolism, and permeability data, setting the groundwork for further investigation into these poorly characterized compounds.”
https://pubmed.ncbi.nlm.nih.gov/37514127/
“In conclusion, fourteen bibenzyl stilbenes have been identified in Cannabis sativa so far, though with the number of compounds identified in the plant ever increasing, more are likely to be characterized over time. The fourteen stilbenes have various degrees of investigational research into their therapeutic potential, with some members, such as dihydroresveratrol and gigantol, being very well characterized due to their presence in other plant sources, while others have just recently been discovered. These compounds show promise as therapeutic agents that could be developed into novel medications for a variety of conditions with further research and development.”
