“Moroccan Cannabis sativa L. seeds were investigated for their phenolic profile and antidiabetic potential.

Ultra-high-performance liquid chromatography with diode array detection and electrospray ionization mass spectrometry analysis revealed a rich phenolic composition, including benzoic acid, cannabisin B, genistein, and epicatechin. 

In vitro, the seed extract exhibited potent α-amylase inhibitory activity (half-maximal inhibitory concentration = 25.02 ± 4.03 μg/mL). In vivo studies in diabetic rats demonstrated significant hypoglycemic, hypolipidemic, hepatoprotective, and nephroprotective effects. Molecular docking studies further supported these findings, revealing strong interactions between identified phenolic and the α-amylase enzyme.

These results highlight the potential of C. sativa seeds as a natural source of bioactive compounds for diabetes management.”

https://pubmed.ncbi.nlm.nih.gov/39822379/

“Our findings demonstrate that C. sativa L. seed extract (CSSE) holds significant promise as a novel therapeutic approach for managing diabetes and its associated complications.”

https://www.degruyter.com/document/doi/10.1515/biol-2022-1024/html