Characterization of the structural determinants required for potent mechanism-based inhibition of human cytochrome P450 1A1 by cannabidiol.

Posted on March 31, 2014 by David

“We previously demonstrated that cannabidiol (CBD) was a potent mechanism-based inhibitor of human cytochrome P450 1A1 (CYP1A1)…

These results suggest that the methylresorcinol structure in CBD may have structurally important roles in the inactivation of CYP1A1.”

http://www.ncbi.nlm.nih.gov/pubmed/24667653

“CYP1A1 regulates breast cancer proliferation and survival. This study supports the notion that CYP1A1 promotes breast cancer proliferation and survival… reduction of CYP1A1 levels is a potential strategy for breast cancer therapeutics.” http://www.ncbi.nlm.nih.gov/pubmed/23576571

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