“Cannabidiol (CBD) is a non-psychoactive plant cannabinoid that inhibits cell proliferation and induces cell death of cancer cells and activated immune cells. It is not an agonist of the classical CB1/CB2 cannabinoid receptors and the mechanism by which it functions is unknown.
…using microscale thermophoresis, we showed a direct interaction between purified fluorescently labeled VDAC1 and CBD.
Thus, VDAC1 seems to serve as a novel mitochondrial target for CBD.
The inhibition of VDAC1 by CBD may be responsible for the immunosuppressive and anticancer effects of CBD.”