Exercise activates the endocannabinoid system.

“Extensive documentation exists showing that exercise induces analgesia and sedation.

…we report here the first evidence that exercise of moderate intensity activates the endocannabinoid system, suggesting a new mechanism for exercise-induced analgesia and possibly other physiological and psychological adaptations to exercise.”

http://www.ncbi.nlm.nih.gov/pubmed/14625449

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