“Altered endocannabinoid (eCB) signaling is suggested as an important contributor to the pathophysiology of depression.

In summary, our data suggest a decreased eCB signalling in the FSL rats, which could contribute to the depressive-like behaviour.

Interestingly, the altered eCB system activity appear to be hemisphere-specific in the limbic regions.

Our study support the existing literature and showed altered eCB system activity in this particular animal model of depression.”

https://www.ncbi.nlm.nih.gov/pubmed/30716357

https://www.sciencedirect.com/science/article/abs/pii/S0197018618305151?via%3Dihub

“Antidepressant-like effect of delta9-tetrahydrocannabinol and other cannabinoids isolated from Cannabis sativa L. Results of this study show that Delta(9)-THC and other cannabinoids exert antidepressant-like actions, and thus may contribute to the overall mood-elevating properties of cannabis.”   https://www.ncbi.nlm.nih.gov/pubmed/20332000