Interleukin-1β causes anxiety by interacting with the endocannabinoid system.

“Interleukin-1β (IL-1β) is involved in mood alterations associated with inflammatory illnesses and with stress. The present investigation identifies a previously unrecognized interaction between a major proinflammatory cytokine and the endocannabinoid system in the pathophysiology of anxiety.”

http://www.ncbi.nlm.nih.gov/pubmed/23035099

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