“Cannabidiol (CBD) is a non-psychotomimetic constituent of Cannabis sativa plant that induces anxiolytic effects… In addition, since CBD has been shown to inhibit anandamide metabolism, CB1 receptors could also be involved in the effects of this cannabinoid…
CBD injected into the dorsolateral periaqueductal gray (dlPAG) produced anxiolytic-like effects… The anxiolytic effect of CBD was confirmed in the Vogel conflict test (VCT)…
CONCLUSION:
These results suggest the CBD interacts with 5HT1A receptors to produce anxiolytic effects in the dlPAG.”