“Some cannabinoids have been shown to suppress chronic pain by targeting glycine receptors (GlyRs).

Although cannabinoid potentiation of α3 GlyRs is thought to contribute to cannabinoid-induced analgesia, the role of cannabinoid potentiation of α1 GlyRs in cannabinoid suppression of chronic pain remains unclear.

Here we report that dehydroxylcannabidiol (DH-CBD), a nonpsychoactive cannabinoid, significantly suppresses chronic inflammatory pain caused by noxious heat stimulation.

These findings suggest that spinal α1 GlyR is a potential target for cannabinoid analgesia in chronic inflammatory pain.”

https://www.ncbi.nlm.nih.gov/pubmed/29407767

https://www.sciencedirect.com/science/article/pii/S0028390818300479