“Muscle pain affects approximately 11-24% of the global population.
Several studies have shown that exercise is a non-pharmacological therapy to pain control. It has been suggested that the endocannabinoid system is involved in this antinociceptive effect.
The present study aimed to investigate whether spinal cannabinoid CB2 receptors participate in the exercise-induced antinociception.
The present study suggests that activation of spinal cannabinoid CB2 receptors and reduction of activated microglia are involved in exercise-induced antinociception.”
https://www.ncbi.nlm.nih.gov/pubmed/31473278
https://www.sciencedirect.com/science/article/abs/pii/S0306452219306165?via%3Dihub