“The endocannabinoid system is composed by a complex and ubiquitous network of endogenous lipid ligands, enzymes for their synthesis and degradation, and receptors, which can also be stimulated by exogenous compounds, such as those derived from the Cannabis sativa. Cannabis and its bioactive compounds, including cannabinoids and non-cannabinoids, have been extensively studied in different conditions.
Recent data have shown that the endocannabinoid system is responsible for maintaining the homeostasis of various skin functions such as proliferation, differentiation and release of inflammatory mediators. Because of their role in regulating these key processes, cannabinoids have been studied for the treatment of skin cancers and melanoma; their anti-tumour effects regulate skin cancer progression and are mainly related to the inhibition of tumour growth, proliferation, invasion and angiogenesis, through apoptosis and autophagy induction. This review aims at summarising the current field of research on the potential uses of cannabinoids in the melanoma field.”
https://pubmed.ncbi.nlm.nih.gov/39039940/
“Cannabinoids exert noteworthy anti-tumour activity in animal models of cancer, but their possible anti-cancer effect in humans has not been established. Further studies should be carried out to optimise the use of cannabinoids in terms of patient selection, combination with other anticancer agents, administration route and delivery schedules. Regarding toxicity, cannabinoids not only show a good safety profile as they carry out their anti-proliferative effects on cancer cells only, but also have palliative effects in patients with cancer.”