“Mitochondrial dysfunction contributes to cell death after cerebral ischemia/reperfusion (I/R) injury.
Cannabinoid CB1 receptor is expressed in neuronal mitochondrial membranes (mtCB1R) and involved in regulating mitochondrial functions under physiological conditions…
In purified neuronal mitochondria, mtCB1R activation attenuated Ca(2+)-induced mitochondrial injury.
In conclusion, mtCB1R is involved in ACEA-induced protective effects on neurons and mitochondrial functions, suggesting mtCB1R may be a potential novel target for the treatment of brain ischemic injury.”