“Cannabinoids produce analgesia in several pain models, but the undesirable side effects from high doses of cannabinoid drugs limit their clinic use.
Our recent results indicate that cannabinoid-induced antinociception was enhanced by neuropeptide VF (NPVF).
Here, we investigate whether low-dose cannabinoid agonists combined with NPVF can produce effective antinociception with limited side effects…
These data suggest that the cannabinoid agonist combined with NPVF produces effective antinociception-lacking tolerance via both cannabinoid receptor type 1 and neuropeptide FF receptors in the brain.”