“Renal cell carcinoma (RCC) is a common urologic tumor with a poor prognosis.
Cannabinoid receptor 1 (CB1), which is a G protein-coupled receptor, has recently been reported to participate in the genesis and development of various cancers.
However, the exact role of CB1 in RCC is unknown. The aim of this study was to determine the role of CB1 in RCC cell lines and RCC prognosis, thus underlying its potential as a therapeutic target.
CB1 expression is functionally associated to cellular proliferation, apoptosis, and invasion ability of RCC.
Our data suggest that CB1 might be a potential target for RCC clinical therapy.”