“In mice, 2,4-dinitrofluorobenzene (DNFB) induces contact allergic dermatitis (CAD), which, in a late phase, is characterized by mast cell (MC) infiltration and angiogenesis.
Palmitoylethanolamide (PEA), an endogenous anti-inflammatory molecule, acts by down-modulating MCs following activation of the cannabinoid CB2 receptor and peroxisome proliferator-activated receptor-α (PPAR-α).
We have previously reported the anti-inflammatory effect of PEA in the early stage of CAD.
Here, we examined whether PEA reduces the features of the late stage of CAD including MC activation, angiogenesis and itching.
PEA, by reducing the features of late stage CAD in mice, may be beneficial in this pathological condition.”