“Colorectal cancer (CRC) is a major health problem in Western countries. The endocannabinoid 2-arachidonoyl-glycerol (2-AG) exerts antiproliferative actions in a number of tumoral cell lines, including CRC cells.
Monoacylglycerol lipase (MAGL), a serine hydrolase that inactivates 2-AG, is highly expressed in aggressive human cancer cells.
Here, we investigated the role of MAGL in experimental colon carcinogenesis.
MAGL, possibly through modulation of angiogenesis, plays a pivotal role in experimental colon carcinogenesis.
Pharmacological inhibition of MAGL could represent an innovative therapeutic approach to reduce colorectal tumor progression.”